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- W1979405087 abstract "The physiological importance of protein kinase C during oligodendrocyte progenitor maturation was investigated by analyzing the effects of the protein kinase C activator phorbol 12-myristate 13-acetate (TPA) on the morphology, proliferation, and differentiation of oligodendrocytes at sequential stages of development. Monoclonal antibodies A2B5 and O4 were used to identify the A2B5+ O4− and the A2B5+ O4+ galactocerebroside− progenitor stages. Anti-galactocerebroside and anti-myelin basic protein were used to identify mature, post-mitotic oligodendrocytes. Proliferation was measured by bromodeoxyuridine incorporation. Within 24 hr after addition, TPA induced a down-regulation of the O4 antigen in OL progenitors, and an increase of expression of the intermediate filament protein vimentin, leading to a phenotypic reversion from the vimentin− A2B5+ O4+ phenotype to the less mature vimentin+ A2B5+ O4− stage. Concomitantly, TPA induced an increase in the number of bromodeoxyuridine-labeled oligodendrocyte progenitors and extensive process elongation. The response of O4+ progenitors was transient. Even with continued exposure to TPA, by 4 days after TPA addition the reverted cells ceased proliferation, reacquired O4 immunoreactivity, became vimentin-negative, and began to express galactocerebroside and myelin basic protein, and to display the complex, highly branched morphology characteristic of terminally differentiated oligodendrocytes. These results indicate that modulation of protein kinase C activity by TPA induces a transient reversion of O4+ progenitors to less mature O4− cells, causing a transient inhibition of terminal differentiation. The relationship of these data to similar responses of the OL lineage to specific growth factors and implications for remyelination after pathologic injury are discussed. © 1993 Wiley-Liss, Inc." @default.
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- W1979405087 date "1993-01-01" @default.
- W1979405087 modified "2023-10-18" @default.
- W1979405087 title "Transient reversion of O4+ Galc− oligodendrocyte progenitor development in response to the phorbol ester TPA" @default.
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- W1979405087 doi "https://doi.org/10.1002/jnr.490340112" @default.
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- W1979405087 hasPublicationYear "1993" @default.
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