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- W1979410029 abstract "The syndrome of late systolic murmur, nonejection click, billowing posterior leaflet, and mild mitral regurgitation is well documented. Electrocardiographic abnormalities consisting of S-T and T-wave changes suggestive of posteroinferior myocardial ischemia are not uncommon. Sudden death, sometimes related to effort, has occasionally occurred. Twelve patients with a late systolic murmur, a nonejection click or both, 5 of whom had an abnormal resting ECG, were subjected to strenuous exercise and the ECG recorded immediately and at intervals thereafter. A striking feature in 3 patients was the appearance, 1 to 2 minutes after cessation of exercise, of numerous multifocal ventricular extrasystoles. Postexercise ECG's after oral propranolol in 2 patients and propranolol plus diphenylhydantoin in the third patient showed disappearance of the ectopic beats. It is suggested that sudden death in this syndrome may be due to ventricular fibrillation preceded by multifocal ventricular extrasystoles. We recommend that a postexercise electrocardiogram be done in all patients with a late systolic murmur or nonejection click. Although papillary muscle dysfunction, secondary to ischemia, may be the cause of billowing of the mitral leaflet in some instances, we believe that leaflet or chordal pathology is the primary abnormality in the majority of cases of this syndrome. The nature of the myocardial pathology remains unknown." @default.
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- W1979410029 date "1970-12-01" @default.
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- W1979410029 title "Postexercise arrhythmias in the billowing posterior mitral leaflet syndrome" @default.
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- W1979410029 doi "https://doi.org/10.1016/0002-8703(70)90134-1" @default.
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