Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979412451> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1979412451 abstract "Kinesin-1 (conventional kinesin) is a homodimeric motor protein important for axonal transport. It has been well studied through ensemble and single-molecule assays. However, the enzymatic stepping cycle is complex, with many rate constants that are modulated by interaction of the two motor domains. This makes it difficult to predict how changes in a given rate constant may affect observable properties such as processivity, velocity, or stall force. We have written a simulation of kinesin walking using a Stochastic Simulation Algorithm. The model allows for interactions between the heads, and includes states that are not considered part of the normal cycle. This adds to the complexity of the model but also allows for probing rare events, such as those that lead to a finite processivity. Also included are rate constant dependencies on force and concentrations of ATP, ADP, and Pi, which may provide insight into other processes under investigation, such as kinesin backstepping. We intend to use the simulation to aid in interpreting our own gliding motility assay results and to place upper and lower limits on values for rate constants. Our source and executable codes will be freely available.Acknowledgements: This work was supported by the DTRA CB Basic Research Program under Grant No. HDTRA1-09-1-008." @default.
- W1979412451 created "2016-06-24" @default.
- W1979412451 creator A5012842609 @default.
- W1979412451 creator A5039775384 @default.
- W1979412451 creator A5045663681 @default.
- W1979412451 creator A5053680979 @default.
- W1979412451 creator A5066626082 @default.
- W1979412451 creator A5075466373 @default.
- W1979412451 date "2010-01-01" @default.
- W1979412451 modified "2023-09-26" @default.
- W1979412451 title "Open-Source Stochastic Simulation for Modeling Kinesin-1 Kinetics" @default.
- W1979412451 doi "https://doi.org/10.1016/j.bpj.2009.12.2004" @default.
- W1979412451 hasPublicationYear "2010" @default.
- W1979412451 type Work @default.
- W1979412451 sameAs 1979412451 @default.
- W1979412451 citedByCount "0" @default.
- W1979412451 crossrefType "journal-article" @default.
- W1979412451 hasAuthorship W1979412451A5012842609 @default.
- W1979412451 hasAuthorship W1979412451A5039775384 @default.
- W1979412451 hasAuthorship W1979412451A5045663681 @default.
- W1979412451 hasAuthorship W1979412451A5053680979 @default.
- W1979412451 hasAuthorship W1979412451A5066626082 @default.
- W1979412451 hasAuthorship W1979412451A5075466373 @default.
- W1979412451 hasBestOaLocation W19794124511 @default.
- W1979412451 hasConcept C121332964 @default.
- W1979412451 hasConcept C12554922 @default.
- W1979412451 hasConcept C131140672 @default.
- W1979412451 hasConcept C160145156 @default.
- W1979412451 hasConcept C160408235 @default.
- W1979412451 hasConcept C181199279 @default.
- W1979412451 hasConcept C186060115 @default.
- W1979412451 hasConcept C199360897 @default.
- W1979412451 hasConcept C20418707 @default.
- W1979412451 hasConcept C32848918 @default.
- W1979412451 hasConcept C41008148 @default.
- W1979412451 hasConcept C46141821 @default.
- W1979412451 hasConcept C59006786 @default.
- W1979412451 hasConcept C62520636 @default.
- W1979412451 hasConcept C82381507 @default.
- W1979412451 hasConcept C86803240 @default.
- W1979412451 hasConcept C95444343 @default.
- W1979412451 hasConceptScore W1979412451C121332964 @default.
- W1979412451 hasConceptScore W1979412451C12554922 @default.
- W1979412451 hasConceptScore W1979412451C131140672 @default.
- W1979412451 hasConceptScore W1979412451C160145156 @default.
- W1979412451 hasConceptScore W1979412451C160408235 @default.
- W1979412451 hasConceptScore W1979412451C181199279 @default.
- W1979412451 hasConceptScore W1979412451C186060115 @default.
- W1979412451 hasConceptScore W1979412451C199360897 @default.
- W1979412451 hasConceptScore W1979412451C20418707 @default.
- W1979412451 hasConceptScore W1979412451C32848918 @default.
- W1979412451 hasConceptScore W1979412451C41008148 @default.
- W1979412451 hasConceptScore W1979412451C46141821 @default.
- W1979412451 hasConceptScore W1979412451C59006786 @default.
- W1979412451 hasConceptScore W1979412451C62520636 @default.
- W1979412451 hasConceptScore W1979412451C82381507 @default.
- W1979412451 hasConceptScore W1979412451C86803240 @default.
- W1979412451 hasConceptScore W1979412451C95444343 @default.
- W1979412451 hasLocation W19794124511 @default.
- W1979412451 hasOpenAccess W1979412451 @default.
- W1979412451 hasPrimaryLocation W19794124511 @default.
- W1979412451 hasRelatedWork W1565750463 @default.
- W1979412451 hasRelatedWork W1856884372 @default.
- W1979412451 hasRelatedWork W1862609577 @default.
- W1979412451 hasRelatedWork W1970986888 @default.
- W1979412451 hasRelatedWork W1979107612 @default.
- W1979412451 hasRelatedWork W1980223215 @default.
- W1979412451 hasRelatedWork W1984473552 @default.
- W1979412451 hasRelatedWork W2022347357 @default.
- W1979412451 hasRelatedWork W2031637767 @default.
- W1979412451 hasRelatedWork W2074147406 @default.
- W1979412451 hasRelatedWork W2099531989 @default.
- W1979412451 hasRelatedWork W2102613806 @default.
- W1979412451 hasRelatedWork W2117415754 @default.
- W1979412451 hasRelatedWork W2118835619 @default.
- W1979412451 hasRelatedWork W2129442406 @default.
- W1979412451 hasRelatedWork W2139170300 @default.
- W1979412451 hasRelatedWork W2145489727 @default.
- W1979412451 hasRelatedWork W2162760560 @default.
- W1979412451 hasRelatedWork W2170121166 @default.
- W1979412451 hasRelatedWork W3022462368 @default.
- W1979412451 isParatext "false" @default.
- W1979412451 isRetracted "false" @default.
- W1979412451 magId "1979412451" @default.
- W1979412451 workType "article" @default.