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- W1979414133 endingPage "667" @default.
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- W1979414133 abstract "Detection, comparison and analyses of binding pockets are pivotal to structure-based drug design endeavors, from hit identification, screening of exosites and de-orphanization of protein functions to the anticipation of specific and non-specific binding to off- and anti-targets. Here, we analyze protein-ligand complexes and discuss methods that assist binding site identification, prediction of druggability and binding site comparison. The full potential of pockets is yet to be harnessed, and we envision that better understanding of the pocket space will have far-reaching implications in the field of drug discovery, such as the design of pocket-specific compound libraries and scoring functions." @default.
- W1979414133 created "2016-06-24" @default.
- W1979414133 creator A5015097541 @default.
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- W1979414133 creator A5051589659 @default.
- W1979414133 creator A5057063821 @default.
- W1979414133 creator A5064154680 @default.
- W1979414133 date "2010-08-01" @default.
- W1979414133 modified "2023-10-01" @default.
- W1979414133 title "Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery" @default.
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