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• W1979414980 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCThe nucleotide excision repair (NER) pathway modulates platinum-based chemotherapeutic efficacy by removal of drug-produced damage to DNA. To determine if NER genes (ERCC1 and ERCC2) influence responses to platinum-based chemotherapies, we performed a meta-analysis in gastric and colorectal cancer for polymorphisms of ERCC1 C118T and ERCC2 Lys751Gln. The analysis included 1413 (451 Asians and 962 Caucasians) cancer patients, who were treated with the platinum-based regimen. The primary outcomes included therapeutic response (TR) as evaluated by complete response + partial response vs. stable disease + progressive disease, progression-free survival (PFS) and overall survival (OS). We calculated odds ratio [OR] or hazard ratio [HR] with 95% confidence intervals [CI] to estimate the risk or hazard in the dominant model. We found consistent and clinically substantial risk or hazard estimates for TR, PFS and OS in the platinum-treated gastroenterology cancer patients. For ERCC1 C118T, we found an ethnical discrepancy in the prognostic values, favoring a pronounced effect in Asians (TR: OR, 0.53 and 95% CI, 0.35-0.81 for four studies of 378 patients; PFS: HR, 1.69 and 95% CI, 1.05-2.70 for five studies of 504 patients; and OS: HR, 1.85 and 95% CI, 1.37-2.48 for four studies of 405 patients, compared with Caucasians: TR: OR, 0.98 and 95% CI, 0.44-2.19 for five studies of 638 patients; PFS: HR, 1.15 and 95% CI, 0.72-1.86 for five studies of 609 patients; and OS: HR, 1.22 and 95% CI, 0.49-3.05 for three studies of 347 patients). For ERCC2 Lys751Gln, the prognostic effect was observed in colorectal cancer for both ethnicities (overall patients: TR: OR, 0.41 and 95% CI, 0.26-0.66 for four studies of 437 patients; PFS: HR, 1.63 and 95% CI, 1.19-2.22 for six studies of 741 patients; and OS: HR, 2.08 and 95% CI, 1.29-3.34 for four studies of 479 patients). This significance remained in Caucasians (TR: OR, 0.41 and 95% CI, 0.23-0.73 for three studies of 249 patients; PFS: HR, 1.55 and 95% CI, 1.08-2.21 for five studies of 553 patients; and OS: HR, 1.64 and 95% CI, 1.23-2.18 for three studies of 291 patients). Based on these results, we concluded that ERCC1 C118T and ERCC2 Lys751Gln polymorphisms might be useful prognostic factors in platinum-treated gastroenterology cancer patients. Further clinical trials are warranted to confirm these findings. (Supported by NIH grants R01CA131274 and R01ES011470)Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3747." @default.
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• W1979414980 date "2010-04-15" @default.
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• W1979414980 title "Abstract 3747: Polymorphisms of ERCC1 C118T and ERCC2 Lys751Gln predict response and prognosis of platinum-treated gastroenterology cancer patients: A finding of pooled meta-analysis" @default.
• W1979414980 doi "https://doi.org/10.1158/1538-7445.am10-3747" @default.
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