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• W1979432882 abstract "The effect of nordihydroguaiaretic acid (NDGA) on Ca2+ signaling in human hepatoma cells (HA22/VGH) has been investigated. NDGA (5–50 μm) increased [Ca2+]i concentration-dependently. The [Ca2+]i increase comprised an initial rise and an elevated phase over a time period of 4 min. Removal of extracellular Ca2+ reduced 10–50 μm NDGA induced [Ca2+]i signals by 45±5%. Consistently, the 50 μm NDGA-induced [Ca2+]i increase in Ca2+-containing medium was reduced by 41±2% by 10 μm of La3+, nifedipine or verapamil. In Ca2+-free medium, pretreatment with 20 μm NDGA for 6 min abolished the [Ca2+]i increase induced by the endoplasmic reticulum Ca2+ pump inhibitor thapsigargin (1 μm). Conversely, 20 μm NDGA failed to increase [Ca2+]i after 1 μm thapsigargin had depleted the endoplasmic reticulum Ca2+ store. Inhibition of phospholipase C with 2 μm U73122 had little effect on 20 μm NDGA-induced Ca2+ release. Several other lipoxygenase inhibitors had no effect on basal [Ca2+]i. Together, the data suggest that NDGA increased [Ca2+]i in hepatocytes in a lipoxygenase-independent manner, by releasing Ca2+ from the endoplasmic reticulum and causing Ca2+ influx." @default.
• W1979432882 created "2016-06-24" @default.
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• W1979432882 date "2002-10-01" @default.
• W1979432882 modified "2023-10-18" @default.
• W1979432882 title "Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in hepatocytes" @default.
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• W1979432882 doi "https://doi.org/10.1016/s0887-2333(02)00051-6" @default.
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