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- W1979442051 abstract "The mammalian kidney, because of its high rate of perfusion, active transport capabilities, and concentrating functions, often is exposed to much higher concentrations of chemicals than are other organs. These high concentrations of chemicals may have no effect on the kidney, may produce a beneficial therapeutic response, or may produce harmful (toxic) effects to the organ. Some chemicals may produce a direct renal cytotoxicity, such as that produced by heavy metals (mercury, chromium), by therapeutic agents (aminoglycoside antibiotics, analgesics), or by a variety of widely used chemicals (chloroform, carbon tetrachloride). Certain other chemicals in the environment may produce biochemical changes in the kidney that alone appear to have no functional correlation (that is, no functional nephropathy can be measured) yet may alter the response of the kidney to other agents. The former chemicals produce identifiable functional lesions that may be life-threatening. Their effects are predictable and dose-related, however. Judicious use of therapeutic agents, careful monitoring of the work place, and so forth, can minimize the dangers of these compounds to man. The latter chemicals, on the other hand, produce no functional lesion and are, therefore, more insidious in their effects and may present more of a hazard to man. The kidney is capable of metabolically altering a wide variety of endogenous and exogenous chemicals. Although many of these reactions produce compounds with reduced biological activity, in some specific instances metabolic transformation of a chemical may result in a compound with greater (or different) biological activity. Metabolism of chemicals within the kidney may, therefore, be an important factor in determining the response of the kidney to chemical exposure. The subject of this article will be the relationships between exposure to environmental pollutants and changes in renal biochemistry that may adversely affect kidney function." @default.
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- W1979442051 date "1980-11-01" @default.
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- W1979442051 title "Effects of environmental chemicals on kidney metabolism and function" @default.
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- W1979442051 doi "https://doi.org/10.1038/ki.1980.182" @default.
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