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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979444838> ?p ?o ?g. }

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• W1979444838 abstract "The discovery of 2′-spirocyclopropyl-ribocytidine as a potent inhibitor of RNA synthesis by NS5B (IC50 = 7.3 μM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the synthesis and biological evaluation of carbocyclic versions of 2′-spiropropyl-nucleosides from cyclopentenol 6. Spirocyclopropylation of enone 7 was completed by using (2-chloroethyl)-dimethylsulfonium iodide and potassium t-butoxide to form the desired intermediate 9a. The synthesized nucleoside analogues, 18, 19, 26, and 27, were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line. The synthesized cytosine nucleoside 19 showed moderate anti-HCV activity (IC50 = 14.4 μM)." @default.
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• W1979444838 date "2011-06-01" @default.
• W1979444838 modified "2023-10-16" @default.
• W1979444838 title "Design and Synthesis of Novel Carbocyclic Versions of 2′-spirocyclopropyl Ribonucleosides as Potent Anti-HCV Agents" @default.
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• W1979444838 doi "https://doi.org/10.1080/15257770.2011.587490" @default.
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