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• W1979445279 abstract "De Riu, P. L., V. Petruzzi, M. A. Caria, O. Mameli, A. R. Casu, S. Nuvoli, A. Spanu and G. Madeddu. β-Endorphin and cortisol levels in plasma and CSF following acute experimental spinal traumas. Physiol Behav 62(1) 1–5, 1997.—β-endorphin and cortisol were measured in cerebrospinal fluid (CSF) and plasma by radioimmunological method (RIA) in two groups of rabbits with spinal cord traumatic injuries at cervical and lumbar levels, respectively with and without concomitant spinal shock and arterial hypotension, and in a group of sham operated animals as controls. The two groups with spinal lesions displayed a significant β-endorphin increase in CSF, whereas the cortisol level remained unchanged both in the spinal traumatized rabbits and in controls. Both the opioid and the cortisol concentration rose significantly in plasma in all three groups and in particular resulted significantly higher in the cervical traumatized group where spinal trauma was associated with spinal shock and hypotension. However, no significant difference was found when β-endorphin concentrations in plasma were compared between the sham operated animals and the spinal lumbar traumatized animals without concomitant spinal shock. The results seem to suggest that the β-endorphin increase in CSF is related to the nervous tissue lesion, while its increase in plasma, like that of cortisol, is due to surgery or other stress factors inherent in the experiment. This independent behaviour of β-endorphin in plasma and in CSF suggests its different origin in these two compartments." @default.
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• W1979445279 date "1997-07-01" @default.
• W1979445279 modified "2023-09-27" @default.
• W1979445279 title "β -Endorphin and Cortisol Levels in Plasma and CSF Following Acute Experimental Spinal Traumas" @default.
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• W1979445279 doi "https://doi.org/10.1016/s0031-9384(97)00099-1" @default.
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