FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979446115> ?p ?o ?g. }

• W1979446115 endingPage "1146" @default.
• W1979446115 startingPage "1137" @default.
• W1979446115 abstract "Anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibodies, such as ipilimumab, have generated measurable immune responses to Melan-A, NY-ESO-1, and gp100 antigens in metastatic melanoma. Vaccination against such targets has potential for immunogenicity and may produce an effector-memory T-cell response. To determine the effect of CTLA-4 blockade on antigen-specific responses following vaccination, in-depth immune monitoring was performed on three ipilimumab-treated patients prevaccinated with gp100 DNA (IMF-24), gp100209–217 and tyrosinase peptides plus GM-CSF DNA (IMF-32), or NY-ESO-1 protein plus imiquimod (IMF-11); peripheral blood mononuclear cells were analyzed by tetramer and/or intracellular cytokine staining following 10-day culture with HLA-A*0201-restricted gp100209–217 (ITDQVPFSV), tyrosinase369–377 (YMDGTMSQV), or 20-mer NY-ESO-1 overlapping peptides, respectively. Tumors from IMF-32 were analyzed by immunohistochemistry to help elucidate mechanism(s) underlying tumor escape. Following vaccination, patients generated weak to no CD4+ or CD8+ T-cell response specific to the vaccine antigen but demonstrated increases in effector-memory (CCR7loCD45RAlo) tetramer+CD8+ T cells. After ipilimumab induction, patients experienced a robust, although sometimes transient, antigen-specific response for gp100 (IMF-32 and IMF-24) or NY-ESO-1 (IMF-11) and produced polyfunctional intracellular cytokines. Primary and metastatic tumors expressed tyrosinase but not gp100 or class I/II MHC molecules. Vaccination induced a measurable antigen-specific T-cell response that increased following CTLA-4 blockade, potentially “boosting” the vaccine-primed response. Tumor escape may be related to antigen loss or lack of MHC expression necessary for immune activity. These results in a limited number of patients support the need for further research into combining vaccination with ipilimumab and provide insight into mechanisms underlying tumor escape." @default.
• W1979446115 created "2016-06-24" @default.
• W1979446115 creator A5003010239 @default.
• W1979446115 creator A5009105564 @default.
• W1979446115 creator A5009336631 @default.
• W1979446115 creator A5009684011 @default.
• W1979446115 creator A5017531113 @default.
• W1979446115 creator A5027415725 @default.
• W1979446115 creator A5027879662 @default.
• W1979446115 creator A5035762260 @default.
• W1979446115 creator A5047117233 @default.
• W1979446115 creator A5054656505 @default.
• W1979446115 creator A5055358847 @default.
• W1979446115 creator A5067541522 @default.
• W1979446115 creator A5089344430 @default.
• W1979446115 creator A5090365102 @default.
• W1979446115 date "2011-04-05" @default.
• W1979446115 modified "2023-10-16" @default.
• W1979446115 title "CTLA-4 blockade increases antigen-specific CD8+ T cells in prevaccinated patients with melanoma: three cases" @default.
• W1979446115 cites W1536480181 @default.
• W1979446115 cites W1542616270 @default.
• W1979446115 cites W1577972394 @default.
• W1979446115 cites W1879616740 @default.
• W1979446115 cites W1944300754 @default.
• W1979446115 cites W1950572133 @default.
• W1979446115 cites W1965504034 @default.
• W1979446115 cites W1967084952 @default.
• W1979446115 cites W2029591487 @default.
• W1979446115 cites W2036032415 @default.
• W1979446115 cites W2039769611 @default.
• W1979446115 cites W2043103956 @default.
• W1979446115 cites W2045932062 @default.
• W1979446115 cites W2049163935 @default.
• W1979446115 cites W2064588363 @default.
• W1979446115 cites W2067930723 @default.
• W1979446115 cites W2070491512 @default.
• W1979446115 cites W2086662659 @default.
• W1979446115 cites W2097995306 @default.
• W1979446115 cites W2099651334 @default.
• W1979446115 cites W2100158834 @default.
• W1979446115 cites W2114329158 @default.
• W1979446115 cites W2115180633 @default.
• W1979446115 cites W2118503880 @default.
• W1979446115 cites W2119088830 @default.
• W1979446115 cites W2119895292 @default.
• W1979446115 cites W2122951893 @default.
• W1979446115 cites W2125160494 @default.
• W1979446115 cites W2128564429 @default.
• W1979446115 cites W2131874142 @default.
• W1979446115 cites W2134638467 @default.
• W1979446115 cites W2134919119 @default.
• W1979446115 cites W2143467222 @default.
• W1979446115 cites W2149244682 @default.
• W1979446115 cites W2157880942 @default.
• W1979446115 cites W2162646864 @default.
• W1979446115 cites W2162856391 @default.
• W1979446115 cites W2164362007 @default.
• W1979446115 cites W2281727437 @default.
• W1979446115 cites W3081413581 @default.
• W1979446115 cites W4245514999 @default.
• W1979446115 doi "https://doi.org/10.1007/s00262-011-1011-9" @default.
• W1979446115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3654853" @default.
• W1979446115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21465316" @default.
• W1979446115 hasPublicationYear "2011" @default.
• W1979446115 type Work @default.
• W1979446115 sameAs 1979446115 @default.
• W1979446115 citedByCount "80" @default.
• W1979446115 countsByYear W19794461152012 @default.
• W1979446115 countsByYear W19794461152013 @default.
• W1979446115 countsByYear W19794461152014 @default.
• W1979446115 countsByYear W19794461152015 @default.
• W1979446115 countsByYear W19794461152016 @default.
• W1979446115 countsByYear W19794461152017 @default.
• W1979446115 countsByYear W19794461152018 @default.
• W1979446115 countsByYear W19794461152019 @default.
• W1979446115 countsByYear W19794461152020 @default.
• W1979446115 countsByYear W19794461152021 @default.
• W1979446115 countsByYear W19794461152022 @default.
• W1979446115 crossrefType "journal-article" @default.
• W1979446115 hasAuthorship W1979446115A5003010239 @default.
• W1979446115 hasAuthorship W1979446115A5009105564 @default.
• W1979446115 hasAuthorship W1979446115A5009336631 @default.
• W1979446115 hasAuthorship W1979446115A5009684011 @default.
• W1979446115 hasAuthorship W1979446115A5017531113 @default.
• W1979446115 hasAuthorship W1979446115A5027415725 @default.
• W1979446115 hasAuthorship W1979446115A5027879662 @default.
• W1979446115 hasAuthorship W1979446115A5035762260 @default.
• W1979446115 hasAuthorship W1979446115A5047117233 @default.
• W1979446115 hasAuthorship W1979446115A5054656505 @default.
• W1979446115 hasAuthorship W1979446115A5055358847 @default.
• W1979446115 hasAuthorship W1979446115A5067541522 @default.
• W1979446115 hasAuthorship W1979446115A5089344430 @default.
• W1979446115 hasAuthorship W1979446115A5090365102 @default.
• W1979446115 hasBestOaLocation W19794461151 @default.
• W1979446115 hasConcept C147483822 @default.
• W1979446115 hasConcept C154317977 @default.
• W1979446115 hasConcept C167672396 @default.
• W1979446115 hasConcept C195616568 @default.

• next