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- W1979451137 startingPage "351" @default.
- W1979451137 abstract "Eye development has been a paradigm for the study of organogenesis, from the demonstration of lens induction through epithelial tissue morphogenesis, to neuronal specification and differentiation. The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific genes and interaction with other regulatory pathways. Herein we examine the data accumulated over the last few decades from extensive analyses of biochemical modules and genetic manipulation of the Pax6 gene. Specifically, we describe the regulation of Pax6’s expression pattern, the protein’s DNA-binding properties, and its specific roles and mechanisms of action at all stages of lens and retinal development. Pax6 functions at multiple levels to integrate extracellular information and execute cell-intrinsic differentiation programs that culminate in the specification and differentiation of a distinct ocular lineage." @default.
- W1979451137 created "2016-06-24" @default.
- W1979451137 creator A5042762792 @default.
- W1979451137 creator A5050980612 @default.
- W1979451137 creator A5058640929 @default.
- W1979451137 creator A5085560121 @default.
- W1979451137 date "2012-09-01" @default.
- W1979451137 modified "2023-10-18" @default.
- W1979451137 title "Pax6: A multi-level regulator of ocular development" @default.
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