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• W1979452570 abstract "The G1/S phase restriction point is a critical checkpoint that interfaces between the cell cycle regulatory machinery and DNA replicator proteins. Here, we report a novel function for the cyclin‐dependent kinase inhibitor p27 Kip1 in inhibiting DNA replication through its interaction with MCM7, a DNA replication protein that is essential for initiation of DNA replication and maintenance of genomic integrity. We find that p27 Kip1 binds the conserved minichromosome maintenance (MCM) domain of MCM7. The proteins interact endogenously in vivo in a growth factor‐dependent manner, such that the carboxyl terminal domain of p27 Kip1 inhibits DNA replication independent of its function as a cyclin‐dependent kinase inhibitor. This novel function of p27 Kip1 may prevent inappropriate initiation of DNA replication prior to S phase." @default.
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• W1979452570 date "2005-11-02" @default.
• W1979452570 modified "2023-10-18" @default.
• W1979452570 title "The cell cycle regulator p27^Kip1interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication" @default.
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• W1979452570 doi "https://doi.org/10.1016/j.febslet.2005.10.028" @default.
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