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• W1979458052 abstract "Baicalein, a flavonoid originally isolated from the root of Scutellaria baicalensis Georgi, has numerous pharmacological activities. Up to now, several studies regarding the pharmacokinetic profiles of baicalein have been described, while there is no such study reported in monkey, the species which is more similar to human. The purpose of this study was to investigate the pharmacokinetic profiles of baicalein after oral administration in monkeys. After orally administrating three doses of baicalein in monkeys, multi-peaks of the plasma concentration–time curves were observed and the non-linear pharmacokinetics for baicalein and its metabolite baicalin were found at doses of 50–500 mg/kg. In order to calculate the absolute bioavailability, the intravenous pharmacokinetic study was also carried out after intravenous administration of 10 mg/kg baicalein. The absolute bioavailability of baicalein in different doses was ranged from 13.1% to 23.0%. In this study, baicalein and baicalin were determined by LC–MS method. The chromatographic separation was performed on Agilent Poroshell 120 SB-C18 column (2.7 μm, 2.1 × 50 mm). Baicalein and baicalin were detected by single quadrupole mass spectrometer equipment with electrospray ionization interface with the selected ion monitoring mode. The assay was linear for both baicalein and baicalin with the correlation coefficients > 0.99. The intra- and inter-day precisions for baicalein and baicalin were all less than 15% by relative standard deviation. The analytes were stable during samples storage and handling, and no matrix effects were observed. The method we developed in this study was sensitive, precise, stable and producible." @default.
• W1979458052 created "2016-06-24" @default.
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• W1979458052 date "2012-04-01" @default.
• W1979458052 modified "2023-10-16" @default.
• W1979458052 title "Pharmacokinetic study of baicalein after oral administration in monkeys" @default.
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• W1979458052 doi "https://doi.org/10.1016/j.fitote.2011.12.019" @default.
• W1979458052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22245084" @default.
• W1979458052 hasPublicationYear "2012" @default.
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