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• W1979465465 abstract "Objective: To determine if the administration of gonadotropins as a single combined injection differs in efficacy when administered once a day (QD) vs. twice a day (BID) in women undergoing IVFDesign: Multicenter, randomized, open-label, assessor-blinded, efficacy, safety, and tolerability study.Materials and Methods: To participate in the study, subjects could be up to 42 years old, have a BMI up to 34.0 and basal FSH up to 15 IU/L. In addition, ICSI, assisted hatching, and co-culture were allowed. Subjects initiated GnRH agonist therapy on day 21 of the previous cycle. Gonadotropin therapy was done in accordance with the usual IVF protocol at each center, with the only requirement being that a minimum of one vial of hMG (Menopur®) had to be used daily in conjunction with human-derived FSH (Bravelle®). In addition, the centers had the option of combining the FSH and hMG and administering it as one single daily injection. The dose and criteria for administering hCG was also left to each center to follow their own protocols. On the day of oocyte retrieval, patients were randomized to one of three treatment arms for luteal support; they either received a novel effervescent vaginal tablet, Endometrin, at a dose of 100 mg BID or TID, or Crinone 8% gel (90 mg) QD.Tabled 1ParameterBravelle + Menopur QD N = 777Bravlle + Menopur BID N = 434P-valueAge32.534.0<.001BMI25.024.9.181Duration10.010.6Oocytes14.013.4.225Cont Pregnancy (%)41.340.6.808 Open table in a new tab Objective: To determine if the administration of gonadotropins as a single combined injection differs in efficacy when administered once a day (QD) vs. twice a day (BID) in women undergoing IVF Design: Multicenter, randomized, open-label, assessor-blinded, efficacy, safety, and tolerability study. Materials and Methods: To participate in the study, subjects could be up to 42 years old, have a BMI up to 34.0 and basal FSH up to 15 IU/L. In addition, ICSI, assisted hatching, and co-culture were allowed. Subjects initiated GnRH agonist therapy on day 21 of the previous cycle. Gonadotropin therapy was done in accordance with the usual IVF protocol at each center, with the only requirement being that a minimum of one vial of hMG (Menopur®) had to be used daily in conjunction with human-derived FSH (Bravelle®). In addition, the centers had the option of combining the FSH and hMG and administering it as one single daily injection. The dose and criteria for administering hCG was also left to each center to follow their own protocols. On the day of oocyte retrieval, patients were randomized to one of three treatment arms for luteal support; they either received a novel effervescent vaginal tablet, Endometrin, at a dose of 100 mg BID or TID, or Crinone 8% gel (90 mg) QD." @default.
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• W1979465465 date "2007-04-01" @default.
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• W1979465465 title "Evaluation of QD vs. BID Dosing of Gonadotropins in Patients Undergoing IVF" @default.
• W1979465465 doi "https://doi.org/10.1016/j.fertnstert.2007.01.206" @default.
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