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- W1979474744 abstract "Nazlinin (1-(4-butylamino)-1,2,3,4-tetrahydro-β-carboline) (1), an alkaloid recently isolated from Nitraria schoberi, and its two derivatives, 1-(4-butylamino)-3,4-dihydro-β-carboline (2) and 1-(4-butylamino)-β-carboline (3), were synthesized and their interaction with pig kidney diamine oxidase (PKDO) was studied. Nazlinin appeared to be a very poor substrate while 3 was a good substrate with an apparent Km of 9.3 · 10−5 M. The enzyme was inhibited by 1 and 2. With both compounds the mode of inhibition found was non-competitive and inhibition constants calculated from the slopes and intercepts of double-reciprocal plots show that 2 is a much more potent inhibitor than the narural product. The relationship between the structure of these compounds and the results found is discussed." @default.
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- W1979474744 date "1995-12-01" @default.
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- W1979474744 title "Inhibition of pig kidney diamine oxidase by nazlinin and nazlinin derivatives" @default.
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- W1979474744 doi "https://doi.org/10.1016/0167-4838(95)00169-5" @default.
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