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• W1979484507 endingPage "1020" @default.
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• W1979484507 abstract "Background: Butyrate has antineoplastic properties against colorectal cancer cells and is the preferred oxidative substrate for colonocytes. Like acetate and propionate (short-chain fatty acids; SCFAs), butyrate is produced by colonic fermentation of dietary fibre. Methods: Twenty patients resected for colorectal cancer were treated with 20 g/day of the fibre Plantago ovuta seeds for 3 months, which increased the intake of fibre by 17.9 ± 0.8 g/day, from basal levels of 19.2 ± 1.7 g/day; 17 patients completed the study. Faecal samples were obtained on eight occasions, twice before treatment, and monthly three times during and three times after treatment. Results: One month of fibre therapy increased faecal concentrations of butyrate by 42 ± 12% (from 13.2 ± 1.2 to 19.3 ± 3.0 mmol/l; P < 10-4), acetate by 25 ± 6% (P < 10-4), propionate by 28 ± 9% (P = 0.01), and total SCFAs by 25 ± 6% (P < 10-4). Concentrations were increased during the 3-month fibre treatment but reversed to pretreatment levels within 1 to 2 months after cessation of fibre supplementation. The relative concentration (ratio) of butyrate was not altered owing to a simultaneous increase in acetate and propionate. Faecal pH decreased initially but was normalized after 2 months of fibre supplements. Fibre therapy increased the 24-h productions of butyrate by 47 ± 10% (P < 10-4) and acetate by 50 ± 7% (P < 10-4) in 16.6% faecal homogenates with added P. ovata seeds (20 mg/ml), but SCFA productions returned to pretreatment levels after discontinuation of additional fibre intakes. Conclusions: Oral intake of P. ovata seeds adapted the colonic flora to increase the production of butyrate (and acetate) from this fibre and increased faecal concentrations of butyrate by 42% in patients resected for colonic cancer. The effects depended on continuity of treatment." @default.
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• W1979484507 date "1996-01-01" @default.
• W1979484507 modified "2023-09-26" @default.
• W1979484507 title "Colonic Production of Butyrate in Patients with Previous Colonic Cancer during Long-Term Treatment with Dietary Fibre (<i>Plantago ovata</i>Seeds)" @default.
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• W1979484507 doi "https://doi.org/10.3109/00365529609003122" @default.
• W1979484507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8898423" @default.
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