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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979489968> ?p ?o ?g. }

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• W1979489968 abstract "The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D human breast tumor cells (66% inhibition at 3 μM). Compound 1 also suppressed hypoxic induction of HIF-1 target genes (VEGF, GLUT-1) at the mRNA level, and displayed tumor cell line-selective time-dependent inhibition of cell viability/proliferation. Mechanistic studies revealed that 1 selectively suppressed mitochondrial respiration at complex I (IC50 3 μM). Thyrsiferol represents a prototypical, structurally unique electron transport chain inhibitor. The apparent rotenone-like activity may contribute to the observed cytotoxicity of 1 and play an important role in Laurencia chemical defense." @default.
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• W1979489968 date "2011-06-01" @default.
• W1979489968 modified "2023-10-14" @default.
• W1979489968 title "Thyrsiferol inhibits mitochondrial respiration and HIF-1 activation" @default.
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• W1979489968 doi "https://doi.org/10.1016/j.phytol.2010.09.003" @default.
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