Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979490775> ?p ?o ?g. }
- W1979490775 endingPage "283" @default.
- W1979490775 startingPage "277" @default.
- W1979490775 abstract "Abstract It has been demonstrated that many flavonoids possess a potent and broad spectrum of antitumor activity. Liquiritigenin is a flavanone extracted from Glycyrrhizae . This study investigated the effects of liquiritigenin on cell viability and apoptosis induction in human cervical carcinoma (HeLa) cells. The results show that liquiritigenin significantly suppressed cell proliferation in a dose‐ and time‐dependent manner in HeLa cells. In addition, liquiritigenin promoted apoptosis in HeLa cells, evidenced by apoptotic morphological changes and Annexin‐V binding. The apoptosis induction with liquiritigenin is associated with the up‐regulation of p53 and Bax, along with down‐regulation of Bcl‐2 and survivin. Finally, examination of the mitochondrial pathway of apoptosis revealed that cytochrome c is released from mitochondria to cytosol, associated with the activation of caspase‐9 and ‐3, and the cleavage of poly (ADP‐ribose) polymerase (PARP). Overall, the results indicate that liquiritigenin induces apoptosis in part via the mitochondrial pathway, which is associated with p53 up‐regulation, release of cytochrome c and elevated activity of caspase‐9 and ‐3 in HeLa cells. Copyright © 2010 John Wiley & Sons, Ltd." @default.
- W1979490775 created "2016-06-24" @default.
- W1979490775 creator A5008102959 @default.
- W1979490775 creator A5010903174 @default.
- W1979490775 creator A5037097714 @default.
- W1979490775 creator A5046483312 @default.
- W1979490775 creator A5089733879 @default.
- W1979490775 creator A5090988600 @default.
- W1979490775 creator A5091223873 @default.
- W1979490775 date "2011-02-01" @default.
- W1979490775 modified "2023-10-17" @default.
- W1979490775 title "Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in heLa Cells" @default.
- W1979490775 cites W1966486313 @default.
- W1979490775 cites W1970360497 @default.
- W1979490775 cites W1972045741 @default.
- W1979490775 cites W1976932448 @default.
- W1979490775 cites W1977764784 @default.
- W1979490775 cites W1982921957 @default.
- W1979490775 cites W1988518686 @default.
- W1979490775 cites W1997054509 @default.
- W1979490775 cites W1997239489 @default.
- W1979490775 cites W2003282032 @default.
- W1979490775 cites W2007010211 @default.
- W1979490775 cites W2026334721 @default.
- W1979490775 cites W2031229197 @default.
- W1979490775 cites W2031695424 @default.
- W1979490775 cites W2036501990 @default.
- W1979490775 cites W2040600751 @default.
- W1979490775 cites W2040712236 @default.
- W1979490775 cites W2043705964 @default.
- W1979490775 cites W2050244937 @default.
- W1979490775 cites W2050452052 @default.
- W1979490775 cites W2057587134 @default.
- W1979490775 cites W2068146558 @default.
- W1979490775 cites W2074152898 @default.
- W1979490775 cites W2077800581 @default.
- W1979490775 cites W2100033931 @default.
- W1979490775 cites W2105000298 @default.
- W1979490775 cites W2116424646 @default.
- W1979490775 cites W2116680419 @default.
- W1979490775 cites W2120487488 @default.
- W1979490775 cites W2121823387 @default.
- W1979490775 cites W2134872883 @default.
- W1979490775 cites W2135924782 @default.
- W1979490775 cites W4245093707 @default.
- W1979490775 doi "https://doi.org/10.1002/ptr.3259" @default.
- W1979490775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20658471" @default.
- W1979490775 hasPublicationYear "2011" @default.
- W1979490775 type Work @default.
- W1979490775 sameAs 1979490775 @default.
- W1979490775 citedByCount "36" @default.
- W1979490775 countsByYear W19794907752012 @default.
- W1979490775 countsByYear W19794907752013 @default.
- W1979490775 countsByYear W19794907752014 @default.
- W1979490775 countsByYear W19794907752015 @default.
- W1979490775 countsByYear W19794907752016 @default.
- W1979490775 countsByYear W19794907752017 @default.
- W1979490775 countsByYear W19794907752019 @default.
- W1979490775 countsByYear W19794907752020 @default.
- W1979490775 countsByYear W19794907752021 @default.
- W1979490775 countsByYear W19794907752022 @default.
- W1979490775 countsByYear W19794907752023 @default.
- W1979490775 crossrefType "journal-article" @default.
- W1979490775 hasAuthorship W1979490775A5008102959 @default.
- W1979490775 hasAuthorship W1979490775A5010903174 @default.
- W1979490775 hasAuthorship W1979490775A5037097714 @default.
- W1979490775 hasAuthorship W1979490775A5046483312 @default.
- W1979490775 hasAuthorship W1979490775A5089733879 @default.
- W1979490775 hasAuthorship W1979490775A5090988600 @default.
- W1979490775 hasAuthorship W1979490775A5091223873 @default.
- W1979490775 hasConcept C12519072 @default.
- W1979490775 hasConcept C142724271 @default.
- W1979490775 hasConcept C1491633281 @default.
- W1979490775 hasConcept C153911025 @default.
- W1979490775 hasConcept C181199279 @default.
- W1979490775 hasConcept C182979987 @default.
- W1979490775 hasConcept C185592680 @default.
- W1979490775 hasConcept C190283241 @default.
- W1979490775 hasConcept C204787440 @default.
- W1979490775 hasConcept C2775975398 @default.
- W1979490775 hasConcept C2777366897 @default.
- W1979490775 hasConcept C2778521916 @default.
- W1979490775 hasConcept C28859421 @default.
- W1979490775 hasConcept C29311851 @default.
- W1979490775 hasConcept C31573885 @default.
- W1979490775 hasConcept C55493867 @default.
- W1979490775 hasConcept C71924100 @default.
- W1979490775 hasConcept C82381507 @default.
- W1979490775 hasConcept C86803240 @default.
- W1979490775 hasConcept C95444343 @default.
- W1979490775 hasConcept C98424977 @default.
- W1979490775 hasConceptScore W1979490775C12519072 @default.
- W1979490775 hasConceptScore W1979490775C142724271 @default.
- W1979490775 hasConceptScore W1979490775C1491633281 @default.
- W1979490775 hasConceptScore W1979490775C153911025 @default.
- W1979490775 hasConceptScore W1979490775C181199279 @default.
- W1979490775 hasConceptScore W1979490775C182979987 @default.
- W1979490775 hasConceptScore W1979490775C185592680 @default.