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• W1979492501 abstract "The recommended treatment for asthma is maintenance therapy with inhaled corticosteroids or combination therapy with an inhaled corticosteroid and a long-acting β2 agonist. 1 Global Initiative for Asthma (GINA)Global strategy for asthma management and prevention: NHLBI/WHO workshop report, publication no. 02–3659. http://www.ginasthma.com/Guidelineitem.asp??l1=2&l2=1&intId=60Date: 2002 Google Scholar , 2 British Thoracic Society (BTS) and Scottish Intercollegiate Guidelines NetworkBritish guideline on the management of asthma. Thorax. 2003; 58: i1-i94 PubMed Google Scholar Furthermore, treatment with a rapid-acting β2 agonist is used as rescue therapy. 1 Global Initiative for Asthma (GINA)Global strategy for asthma management and prevention: NHLBI/WHO workshop report, publication no. 02–3659. http://www.ginasthma.com/Guidelineitem.asp??l1=2&l2=1&intId=60Date: 2002 Google Scholar , 2 British Thoracic Society (BTS) and Scottish Intercollegiate Guidelines NetworkBritish guideline on the management of asthma. Thorax. 2003; 58: i1-i94 PubMed Google Scholar When the asthma is not controlled, the level of maintenance therapy should be increased. This strategy has recently been challenged by studies that suggest the use of an inhaled corticosteroid and a long-acting β2 agonist in one inhaler for both maintenance and as-needed therapy. 3 O'Byrne PM Bisgaard H Godard PP et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med. 2005; 171: 129-136 Crossref PubMed Scopus (573) Google Scholar Because this option necessarily increases the use of two different drugs, the question has been raised as to their relative contribution to the additional clinical effects. In today's Lancet, Klaus Rabe and colleagues 4 Rabe KF Atienza T Magyar P Larsson P Jorup C Lalloo UG Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet. 2006; 368: 744-753 Summary Full Text Full Text PDF PubMed Scopus (348) Google Scholar report the findings of a study designed to address that question by comparing the effects of as-needed treatment with terbutaline, formoterol, and the combination of formoterol and budesonide in one inhaler on daily asthma control and the occurrence of asthma exacerbations in patients whose asthma is not controlled on treatment with a formoterol/budesonide 4·5/160 μg combination twice daily. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind studyBoth monocomponents of budesonide-formoterol given as needed contribute to enhanced protection from severe exacerbations in patients receiving combination therapy for maintenance. Full-Text PDF" @default.
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• W1979492501 date "2006-08-01" @default.
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• W1979492501 title "Budesonide plus formoterol for reliever therapy in asthma" @default.
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• W1979492501 doi "https://doi.org/10.1016/s0140-6736(06)69260-x" @default.
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