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- W1979495655 abstract "An automated analytical procedure is described for the parallel determination of l-3,4-dihydroxyphenylalanine (levodopa, l-dopa, LD) and the analogous hydrazine compound carbidopa (CD) in dog plasma by ion-pair high-performance liquid chromatography with electrochemical detection (HPLC-ED). After deproteinization of the plasma samples with perchloric acid the catecholamines were extracted from the supernatant by adsorption on a small column filled with alumina. The extraction and redissolution were automatically performed in a flow injection analysis unit (FIA) coupled to the HPLC system. The performance of the whole system was tested on dog plasma samples including specimens taken after oral administration of the anti-Parkinsonism drug Duellin®, which is a combination tablet of levodopa and carbidopa." @default.
- W1979495655 created "2016-06-24" @default.
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- W1979495655 date "1991-04-01" @default.
- W1979495655 modified "2023-10-16" @default.
- W1979495655 title "Determination of l-3,4-dihydroxyphenylalanine in biological fluids and tissues" @default.
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- W1979495655 doi "https://doi.org/10.1016/0378-4347(91)80366-k" @default.
- W1979495655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1908475" @default.
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