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• W1979503040 endingPage "381" @default.
• W1979503040 startingPage "374" @default.
• W1979503040 abstract "Herein we report the preparation along with the in vivo and in vitro MRI characterization of two generation four and five cystamine core dendrimers loaded with thirty and fifty-eight derivatized Gd-DOTA (G4SS30, G5SS58) respectively. Likewise the development and characterization of two half-dendrimers conjugated to the F(ab′)2 fragment of the monoclonal antibody (mAb) panitumumab functionalized with a maleimide conjugation functional group site (Ab–(G4S15)4, Ab–(G5S29)4) are also described. The in vitro molar relaxivity of the Ab–(G4S15)4 conjugate, measured at pH 7.4, 22 °C, and 3T showed a moderate increase in relaxivity as compared to Magnevist (6.7 vs 4.0 mM–1 s–1) while the Ab–(G5S29)4 conjugate was 2-fold higher (9.1 vs 4.0 mM–1 s–1). The data showed that only a high injection dose (0.050 mmol Gd3+/kg) produced a detectable contrast enhanced contrast for the Ab–(G4S15)4 conjugate while a lower dose (0.035 mmol Gd3+/kg) was sufficient for the Ab–(G5S29)4 conjugate. The antibody–SMCC conjugate was purified by a Sephadex G-100 column, and the antibody-dendrimer-based agents were purified by spin filtration using a Centricon filter (50,000 MCO). The protein assay coupled with cysteine and Ellman’s assay indicated an antibody to dendrimer ratio of 1:4. The in vivo blood clearance half-lives of the four agents measured at the jugular vein were ∼12–22 min." @default.
• W1979503040 created "2016-06-24" @default.
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• W1979503040 date "2011-09-21" @default.
• W1979503040 modified "2023-10-07" @default.
• W1979503040 title "Preparation of Cystamine Core Dendrimer and Antibody–Dendrimer Conjugates for MRI Angiography" @default.
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• W1979503040 doi "https://doi.org/10.1021/mp2003219" @default.
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