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- W1979511107 abstract "In vitro and in vivo evaluations have been made of the salicylate release characteristics of aspirin coated by the Wurster process. The films used were of methyl and ethyl cellulose plasticized by glycerol. The in vitro release rates of such coatings were shown to be first order. The in vivo release may be best represented as first order. A mathematical correlation between in vivo and in vitro rates is possible, but this correlation is directly dependent on film composition. It is shown that the slower the release pattern, the less complete is the apparent plasma availability, due to incomplete physical release and insufficient time for complete biologic absorption. In vitro and in vivo evaluations have been made of the salicylate release characteristics of aspirin coated by the Wurster process. The films used were of methyl and ethyl cellulose plasticized by glycerol. The in vitro release rates of such coatings were shown to be first order. The in vivo release may be best represented as first order. A mathematical correlation between in vivo and in vitro rates is possible, but this correlation is directly dependent on film composition. It is shown that the slower the release pattern, the less complete is the apparent plasma availability, due to incomplete physical release and insufficient time for complete biologic absorption." @default.
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- W1979511107 date "1964-08-01" @default.
- W1979511107 modified "2023-10-09" @default.
- W1979511107 title "Wurster Coated Aspirin II" @default.
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- W1979511107 doi "https://doi.org/10.1002/jps.2600530806" @default.
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