FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979511150> ?p ?o ?g. }

• W1979511150 endingPage "3026" @default.
• W1979511150 startingPage "3017" @default.
• W1979511150 abstract "Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precursor of NO, and is used as a supplement in the US. In the present study, we evaluated whether the administration of L-arginine alone improves insulin resistance and serum lipid levels in insulin-resistant and hypertriglycemic rat models. Diabetic rats were divided into 3 groups: the control (Cont) group (standard diet), the L-NAME group (diet containing L-NAME), and the Arg group (diet containing L-arginine). After 4 weeks of breeding, urinary NOx, glucose infusion rate (GIR), glucose and lipid tolerance tests were performed. Urinary NOx levels were significantly lower in the L-NAME group than in the Cont group. The GIR in the L-NAME group was significantly lower than that in the Cont group, suggesting increased insulin resistance. However, the administration of L-arginine did not influence insulin resistance in the Arg group. Oral lipid administration significantly increased plasma triglyceride levels in the L-NAME group and plasma triglyceride levels were significantly lower in the Arg group than in the Cont group. The area under the curve of plasma triglyceride levels after oral lipid administration was larger in the L-NAME group than in the Cont group. The administration of L-NAME increased insulin resistance and decreased lipid metabolism. L-arginine significantly increased urinary NO secretion but did not improve insulin resistance, although it did improve lipid metabolism. These findings suggest that supplementation of L-arginine cannot improve insulin resistance in diabetic rats probably due to increased insulin secretion by L-arginine." @default.
• W1979511150 created "2016-06-24" @default.
• W1979511150 creator A5005079654 @default.
• W1979511150 creator A5014761407 @default.
• W1979511150 creator A5038923350 @default.
• W1979511150 creator A5058981902 @default.
• W1979511150 creator A5058999827 @default.
• W1979511150 date "2003-10-01" @default.
• W1979511150 modified "2023-10-18" @default.
• W1979511150 title "Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats" @default.
• W1979511150 cites W1782753704 @default.
• W1979511150 cites W1823480916 @default.
• W1979511150 cites W1928175618 @default.
• W1979511150 cites W1973372369 @default.
• W1979511150 cites W1976851726 @default.
• W1979511150 cites W1977189254 @default.
• W1979511150 cites W1978337405 @default.
• W1979511150 cites W2012127764 @default.
• W1979511150 cites W2023352512 @default.
• W1979511150 cites W2038364289 @default.
• W1979511150 cites W2050967471 @default.
• W1979511150 cites W2066460470 @default.
• W1979511150 cites W2080287320 @default.
• W1979511150 cites W2118295133 @default.
• W1979511150 cites W2122603966 @default.
• W1979511150 cites W2123208560 @default.
• W1979511150 cites W2124948826 @default.
• W1979511150 cites W2132666492 @default.
• W1979511150 cites W2136841005 @default.
• W1979511150 cites W2144188723 @default.
• W1979511150 cites W2150766847 @default.
• W1979511150 cites W2168526937 @default.
• W1979511150 cites W4231154278 @default.
• W1979511150 cites W4248842722 @default.
• W1979511150 cites W4256091557 @default.
• W1979511150 doi "https://doi.org/10.1016/j.lfs.2003.06.004" @default.
• W1979511150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14519450" @default.
• W1979511150 hasPublicationYear "2003" @default.
• W1979511150 type Work @default.
• W1979511150 sameAs 1979511150 @default.
• W1979511150 citedByCount "26" @default.
• W1979511150 countsByYear W19795111502012 @default.
• W1979511150 countsByYear W19795111502013 @default.
• W1979511150 countsByYear W19795111502014 @default.
• W1979511150 countsByYear W19795111502015 @default.
• W1979511150 countsByYear W19795111502016 @default.
• W1979511150 countsByYear W19795111502017 @default.
• W1979511150 countsByYear W19795111502018 @default.
• W1979511150 countsByYear W19795111502019 @default.
• W1979511150 countsByYear W19795111502021 @default.
• W1979511150 crossrefType "journal-article" @default.
• W1979511150 hasAuthorship W1979511150A5005079654 @default.
• W1979511150 hasAuthorship W1979511150A5014761407 @default.
• W1979511150 hasAuthorship W1979511150A5038923350 @default.
• W1979511150 hasAuthorship W1979511150A5058981902 @default.
• W1979511150 hasAuthorship W1979511150A5058999827 @default.
• W1979511150 hasConcept C126322002 @default.
• W1979511150 hasConcept C134018914 @default.
• W1979511150 hasConcept C185592680 @default.
• W1979511150 hasConcept C2777391703 @default.
• W1979511150 hasConcept C2777468819 @default.
• W1979511150 hasConcept C2778163477 @default.
• W1979511150 hasConcept C2778270857 @default.
• W1979511150 hasConcept C2778913445 @default.
• W1979511150 hasConcept C2779306644 @default.
• W1979511150 hasConcept C4733338 @default.
• W1979511150 hasConcept C515207424 @default.
• W1979511150 hasConcept C519581460 @default.
• W1979511150 hasConcept C55493867 @default.
• W1979511150 hasConcept C555293320 @default.
• W1979511150 hasConcept C71924100 @default.
• W1979511150 hasConceptScore W1979511150C126322002 @default.
• W1979511150 hasConceptScore W1979511150C134018914 @default.
• W1979511150 hasConceptScore W1979511150C185592680 @default.
• W1979511150 hasConceptScore W1979511150C2777391703 @default.
• W1979511150 hasConceptScore W1979511150C2777468819 @default.
• W1979511150 hasConceptScore W1979511150C2778163477 @default.
• W1979511150 hasConceptScore W1979511150C2778270857 @default.
• W1979511150 hasConceptScore W1979511150C2778913445 @default.
• W1979511150 hasConceptScore W1979511150C2779306644 @default.
• W1979511150 hasConceptScore W1979511150C4733338 @default.
• W1979511150 hasConceptScore W1979511150C515207424 @default.
• W1979511150 hasConceptScore W1979511150C519581460 @default.
• W1979511150 hasConceptScore W1979511150C55493867 @default.
• W1979511150 hasConceptScore W1979511150C555293320 @default.
• W1979511150 hasConceptScore W1979511150C71924100 @default.
• W1979511150 hasIssue "23" @default.
• W1979511150 hasLocation W19795111501 @default.
• W1979511150 hasLocation W19795111502 @default.
• W1979511150 hasOpenAccess W1979511150 @default.
• W1979511150 hasPrimaryLocation W19795111501 @default.
• W1979511150 hasRelatedWork W138803513 @default.
• W1979511150 hasRelatedWork W1983641721 @default.
• W1979511150 hasRelatedWork W1986132654 @default.
• W1979511150 hasRelatedWork W2010140898 @default.
• W1979511150 hasRelatedWork W2010236753 @default.
• W1979511150 hasRelatedWork W2082140668 @default.
• W1979511150 hasRelatedWork W2169206971 @default.

• next