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- W1979522072 abstract "The microsomal brush-border fraction of rat renal tissue contains enzymatic activity, optimally active at pH 9, that is capable of degrading human myelin basic protein (BP) peptide 43–88. In the present study, this degradation and the effect on it selected drugs and hormones were examined further. Of the substances tested, 10−2M chloroquine and 10−5M ACTH 1–24 were found to be the most effective inhibitors followed by 10−5M ACTH 1–39; parathormone, glucagon and insulin were found to be inhibitors an order of magnitude weaker than ACTH 1–24. Hydrocortisone, dexamethasone, maleic acid and ACTH 4–10 were found to have minimal or no inhibitory effect on the peptide degrading activity. Gel filtration of the degradation products indicated that the rate of degradation of BP peptide 43–88 at pH 9 had been retarded by ACTH 1–24. These studies indicate that the clearance and catabolism of this peptide may be altered by available therapeutic agents." @default.
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- W1979522072 date "1985-04-01" @default.
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- W1979522072 title "Hormonal and drug effects on the degradation of human myelin basic protein peptide 43–88 by alkaline proteolytic activity in the rat kidney" @default.
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- W1979522072 doi "https://doi.org/10.1016/0006-2952(85)90500-3" @default.
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