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- W1979522191 abstract "Purpose To investigate a simple semiquantitative method to estimate yttrium-90 (90Y) dose delivered with radioembolization to infiltrative hepatocellular carcinoma (HCC). Materials and Methods In a prospective study, patients with infiltrative HCC and portal vein thrombosis (PVT) underwent glass-based 90Y radioembolization including technetium-99m macroaggregated albumin (99mTc-MAA) hepatopulmonary shunt study before therapy and bremsstrahlung single photon emission computed tomography (SPECT)/computed tomography (CT) after 90Y radioembolization. Baseline magnetic resonance imaging was coregistered with 99mTc-MAA and bremsstrahlung SPECT/CT imaging separately. Unit tumor activity (90Y radioactivity delivered to each cubic centimeter of tumor) was estimated based on a lobar infusion approach. Correlation between proportions of 99mTc-MAA and 90Y delivered to the tumor was investigated. Survival analysis was performed using Kaplan-Meier estimations. Results 90Y therapy was administered in 18 consecutive patients (median age, 55.3 y; mean tumor volume, 588 cm3). Higher intratumoral 90Y dose predicted prolonged survival, with 13.2-month median survival in patients with HCC and mean 90Y dose of ≥ 100 Gy versus 4.6-month median survival for other patients (P < .001). Of administered 90Y dose, 51.9% was delivered to the targeted tumors compared with 74.1% of 99mTc-MAA with linear correlation between biodistribution of 99mTc-MAA and 90Y observed (Pearson r = 0.774, P < .001). Conclusions The findings in this study suggest that approximately 50% of administered 90Y dose is taken up by targeted infiltrative HCC with PVT. Intratumoral 90Y dose ≥ 100 Gy in unresectable infiltrative HCC via a lobar intraarterial approach is a positive prognostic factor for survival." @default.
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- W1979522191 date "2014-02-01" @default.
- W1979522191 modified "2023-09-25" @default.
- W1979522191 title "A Simple Method for Estimating Dose Delivered to Hepatocellular Carcinoma after Yttrium-90 Glass-Based Radioembolization Therapy: Preliminary Results of a Proof of Concept Study" @default.
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- W1979522191 doi "https://doi.org/10.1016/j.jvir.2013.11.007" @default.
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