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• W1979532854 abstract "Spherical crystal agglomeration of ibuprofen was performed in the presence of Eudragit® S100 using the solvent-change (ethanol–water) method and applying different crystallisation conditions such as initial supersaturation under both increasing and constant drug:polymer ratios and different rates of stirring and cooling. The temperature in the crystallisation liquid and water consumption were recorded to determine the effects of polymer presence on crystallisation parameters (drug loading efficiency, crystal yield and mean `apparent crystal growth' rate) and to correlate them with the physicomechanical properties of the agglomerates. It was found that crystal yield and drug loading efficiency are not affected by the crystallisation conditions, while the mean `apparent crystal growth' rate increases with initial supersaturation ratio and stirring rate; however, the cooling effect is stirring dependent, probably due to changes in the nucleation mechanism. The particle size of agglomerates decreases, while sphericity, surface roughness and intraparticle porosity increase with polymer presence. Also, particle size and sphericity decrease, while intraparticle porosity increases with initial supersaturation. The effects of Eudragit® addition on the fundamental particle properties are attributed to the habit and growth rate changes of ibuprofen microcrystals, as well as to their coating before binding into spherical agglomerates. The stirring rate effect on particle size is enhanced by slow cooling, and sphericity becomes maximal at slow cooling and fast stirring. The size and sphericity changes due to stirring and cooling are attributed to the polymer binding ability and to detachment of small fragments from the agglomerate surface. Flow or packing behaviour and densification of agglomerates at low compression are determined by the sphericity changes and their yield pressure by the brittleness due to the incorporated polymer." @default.
• W1979532854 created "2016-06-24" @default.
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• W1979532854 date "1998-10-01" @default.
• W1979532854 modified "2023-09-27" @default.
• W1979532854 title "Crystallisation conditions and physicomechanical properties of ibuprofen–Eudragit® S100 spherical crystal agglomerates prepared by the solvent-change technique" @default.
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• W1979532854 doi "https://doi.org/10.1016/s0378-5173(98)00191-4" @default.
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