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- W1979540187 abstract "The mechanism of Fv-1 restriction in DBA/2 (Fv-1n) mouse cells was investigated by quantitative infectious center assays employing a newly isolated continuous cell line. Titration of B-tropic murine leukemia virus (MuLV) in DBA/2 cells showed two-hit kinetics and, at sufficient multiplicities of infection (MOIs), the entire cell population could be productively infected with the restricted virus. Infection of DBA/2 cells with a single particle of B-tropic (but not with N- or NB-tropic) MuLV which had been inactivated at 43°C rendered the cells permissive to superinfection with B-tropic MuLV. This effect was time-dependent, the cells becoming permissive to B-tropic MuLV by 3 h after the initial infection and regaining their restriction within 18 h. These findings, which are similar to our previous results on the infection of BALB/3T3 (Fv-1b) cells with N-tropic MuLV, indicate that two B-tropic MuLV particles are required for successful infection of a DBA/2 cell in this non-permissive system. These two particles appear to be functionally different: one temporarily overcomes or “abrogates” Fv-1 restriction but need not replicate, while the second apparently undergoes a normal replication cycle. Two other Fv-1n cell lines, NIH/3T3 and C3H 10T1/2, gave results which were not analogous to those obtained on DBA/2 cells. Even at high MOIs, only about 10–20% of NIH/3T3 or C3H 10T1/2 cells could be infected with B-tropic MuLV. These quantitative differences in titration patterns indicate that NIH/3T3 and C3H 10T1/2 cells have different mechanisms of Fv-1n restriction from that of DBA/2 cells, or, more likely, that they possess other restriction systems in addition to Fv-1." @default.
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- W1979540187 date "1979-11-15" @default.
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- W1979540187 title "Mechanism of restriction of murine leukemia viruses varies between different strains of Fv-1n mice" @default.
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- W1979540187 doi "https://doi.org/10.1002/ijc.2910240513" @default.
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