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• W1979540318 abstract "Specific IgE binding to carbohydrate moieties of glycosylated allergens has been known for years, but the importance of these structures for the elicitation of allergic reactions is still a matter of debate. Because of their conserved carbohydrate structures, especially N-glycans have always been prime candidates for IgE cross-reactivity between allergens from unrelated species. The aim of our study was to determine whether carbohydrate structures on glycoproteins can by themselves elucidate allergic reactions. We characterized in detail the carbohydrate moieties of the major allergens Phl p 1 and Phl p 13 of timothy grass pollen (Phleum pratense L.) by performing tryptic digests followed by HPLC, Nterminal sequencing, sugar analysis, MALDI-TOF- and ESI-ICR-FT-MS. Phl p 1 contains one N-glycan with one of the two glycoforms MMXF[3] and M0XF[3] and a single furanosidic arabinose, which is bound to a hydroxyproline residue in direct vicinity to the N-glycan. This O-glycosylation is probably due to an arabinosylation consensus sequence found in the N-terminal part of Phl p 1 and other group 1 allergens, but displayed no IgE-reactivity. Thus, Phl p 1 is monovalent with respect to its IgE-binding carbohydrate epitopes and showed no mediator release. In contrast, the carbohydrate moiety of Phl p 13, which carries four of the same N-glycans (like Phl p 1), can crosslink IgE-receptors via carbohydrate chains and elicits IL-4 release from basophils." @default.
• W1979540318 created "2016-06-24" @default.
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• W1979540318 date "2004-01-14" @default.
• W1979540318 modified "2023-10-16" @default.
• W1979540318 title "Carbohydrate moieties can induce mediator release: a detailed characterization of two major timothy grass pollen allergens" @default.
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• W1979540318 doi "https://doi.org/10.1515/bc.2004.044" @default.
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