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- W1979542999 abstract "Abstract Epithelial/Burkitt hybrid cells (D98/HR-1) typically express the Epstein-Barr-associated nuclear antigen (EBNA). Synthesis of early antigen (EA) and virus capsid antigen (VCA) is repressed. Following treatment with 5-iodo-2′-deoxyuridine (IUdR), however, Epstein-Barr virus (EBV) EA and late virus-specific products, including EBV DNA and complete virions, are induced. This report demonstrates that phosphonoacetic acid inhibits expression of VCA, but has no effect on EA. Cells treated with IUdR were also found to express a new DNA polymerase which was susceptible to stimulation by salt and was not present in uninduced cells. This salt-stimulated DNA polymerase resembles other herpesvirus-induced DNA polymerases in its requirements for maximal activity and its ability to use synthetic templates in DNA synthesis. Data suggest that this DNA polymerase is induced by EBV and is necessary for the productive synthesis of virus-specific DNA." @default.
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- W1979542999 date "1977-02-01" @default.
- W1979542999 modified "2023-09-26" @default.
- W1979542999 title "Studies of an epstein-barr virus-induced DNA polymerase" @default.
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- W1979542999 doi "https://doi.org/10.1016/0042-6822(77)90232-x" @default.
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