Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979557488> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1979557488 endingPage "121" @default.
- W1979557488 startingPage "114" @default.
- W1979557488 abstract "Differential DNA heteroduplex patterns were used to investigate inheritance of HLA class II region genes in a family where a living related kidney transplant was under consideration. Serologic typing of the family members for HLA class I (HLA-A, B, and C) and class II (HLA-DR and DQ) alleles indicated that the patient (109) and one sibling (126) had inherited the same maternal and paternal HLA alleles. However, a strong reciprocal mixed lymphocyte response implied that these two individuals were not completely HLA identical. Serologic typing for HLA-DQ was confirmed by allele-specific oligonucleotide typing family members for HLA-DQα and β genes. To assess a possible nonidentical gene(s), DNA was amplified from all family members at the second exon of the DRβ, DQα, DPα, and DPβ genes and the products were analyzed by DNA heteroduplex formation. This method showed that individuals 109 and 126 were identical at DR and DQ but differed at DP. This difference was confirmed by allele-specific oligonucleotide hybridization and indicated that 126 had inherited a recombinant maternal chromosome with a cross-over occurring in the region between the DQβ and DPα genes. These data demonstrate the applicability of DNA heteroduplex patterns in establishing identity-nonidentity of alleles in the major histocompatibility complex." @default.
- W1979557488 created "2016-06-24" @default.
- W1979557488 creator A5015037227 @default.
- W1979557488 creator A5015541994 @default.
- W1979557488 creator A5025685764 @default.
- W1979557488 creator A5043257267 @default.
- W1979557488 creator A5058798835 @default.
- W1979557488 date "1992-02-01" @default.
- W1979557488 modified "2023-09-27" @default.
- W1979557488 title "The use of DNA heteroduplex patterns to map recombination within the HLA class II region" @default.
- W1979557488 cites W1561644389 @default.
- W1979557488 cites W1963642947 @default.
- W1979557488 cites W1979137280 @default.
- W1979557488 cites W1992368452 @default.
- W1979557488 cites W1997521650 @default.
- W1979557488 cites W2002837417 @default.
- W1979557488 cites W2006714565 @default.
- W1979557488 cites W2032118018 @default.
- W1979557488 cites W2044692125 @default.
- W1979557488 cites W2062622653 @default.
- W1979557488 cites W2090064498 @default.
- W1979557488 cites W2090928487 @default.
- W1979557488 cites W2207584063 @default.
- W1979557488 cites W2321157084 @default.
- W1979557488 cites W66527107 @default.
- W1979557488 doi "https://doi.org/10.1016/0198-8859(92)90061-q" @default.
- W1979557488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1532959" @default.
- W1979557488 hasPublicationYear "1992" @default.
- W1979557488 type Work @default.
- W1979557488 sameAs 1979557488 @default.
- W1979557488 citedByCount "21" @default.
- W1979557488 crossrefType "journal-article" @default.
- W1979557488 hasAuthorship W1979557488A5015037227 @default.
- W1979557488 hasAuthorship W1979557488A5015541994 @default.
- W1979557488 hasAuthorship W1979557488A5025685764 @default.
- W1979557488 hasAuthorship W1979557488A5043257267 @default.
- W1979557488 hasAuthorship W1979557488A5058798835 @default.
- W1979557488 hasConcept C104317684 @default.
- W1979557488 hasConcept C134494468 @default.
- W1979557488 hasConcept C147483822 @default.
- W1979557488 hasConcept C153911025 @default.
- W1979557488 hasConcept C180754005 @default.
- W1979557488 hasConcept C188280979 @default.
- W1979557488 hasConcept C202965653 @default.
- W1979557488 hasConcept C2781209916 @default.
- W1979557488 hasConcept C54355233 @default.
- W1979557488 hasConcept C86803240 @default.
- W1979557488 hasConceptScore W1979557488C104317684 @default.
- W1979557488 hasConceptScore W1979557488C134494468 @default.
- W1979557488 hasConceptScore W1979557488C147483822 @default.
- W1979557488 hasConceptScore W1979557488C153911025 @default.
- W1979557488 hasConceptScore W1979557488C180754005 @default.
- W1979557488 hasConceptScore W1979557488C188280979 @default.
- W1979557488 hasConceptScore W1979557488C202965653 @default.
- W1979557488 hasConceptScore W1979557488C2781209916 @default.
- W1979557488 hasConceptScore W1979557488C54355233 @default.
- W1979557488 hasConceptScore W1979557488C86803240 @default.
- W1979557488 hasIssue "2" @default.
- W1979557488 hasLocation W19795574881 @default.
- W1979557488 hasLocation W19795574882 @default.
- W1979557488 hasOpenAccess W1979557488 @default.
- W1979557488 hasPrimaryLocation W19795574881 @default.
- W1979557488 hasRelatedWork W1545913120 @default.
- W1979557488 hasRelatedWork W1992101497 @default.
- W1979557488 hasRelatedWork W2077346610 @default.
- W1979557488 hasRelatedWork W2098918063 @default.
- W1979557488 hasRelatedWork W2108786330 @default.
- W1979557488 hasRelatedWork W2140847347 @default.
- W1979557488 hasRelatedWork W2411054033 @default.
- W1979557488 hasRelatedWork W2427947769 @default.
- W1979557488 hasRelatedWork W2786976020 @default.
- W1979557488 hasRelatedWork W65935823 @default.
- W1979557488 hasVolume "33" @default.
- W1979557488 isParatext "false" @default.
- W1979557488 isRetracted "false" @default.
- W1979557488 magId "1979557488" @default.
- W1979557488 workType "article" @default.