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• W1979566467 endingPage "525" @default.
• W1979566467 startingPage "513" @default.
• W1979566467 abstract "Endomembranes modify the progression of the cytosolic Ca(2+) wave and contribute to generate Ca(2+) microdomains, both in the cytosol and inside the own organella. The concentration of Ca(2+) in the cytosol ([Ca(2+)](C)), the mitochondria ([Ca(2+)](M)) and the nucleus ([Ca(2+)](N)) are similar at rest, but may become very different during cell activation. Mitochondria avidly take up Ca(2+) from the high [Ca(2+)](C) microdomains generated during cell activation near Ca(2+) channels of the plasma membrane and/or the endomembranes and prevent propagation of the high Ca(2+) signal to the bulk cytosol. This shaping of [Ca(2+)](C) signaling is essential for independent regulation of compartmentalized cell functions. On the other hand, a high [Ca(2+)](M) signal is generated selectively in the mitochondria close to the active areas, which tunes up respiration to the increased local needs. The progression of the [Ca(2+)](C) signal to the nucleus may be dampened by mitochondria, the nuclear envelope or higher buffering power inside the nucleoplasm. On the other hand, selective [Ca(2+)](N) signals could be generated by direct release of stored Ca(2+) into the nucleoplasm. Ca(2+) release could even be restricted to subnuclear domains. Putative Ca(2+) stores include the nuclear envelope, their invaginations inside the nucleoplasm (nucleoplasmic reticulum) and nuclear microvesicles. Inositol trisphosphate, cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate have all been reported to produce release of Ca(2+) into the nucleoplasm, but contribution of these mechanisms under physiological conditions is still uncertain." @default.
• W1979566467 created "2016-06-24" @default.
• W1979566467 creator A5011206390 @default.
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• W1979566467 creator A5068316025 @default.
• W1979566467 date "2006-11-01" @default.
• W1979566467 modified "2023-10-18" @default.
• W1979566467 title "Calcium microdomains in mitochondria and nucleus" @default.
• W1979566467 cites W111330927 @default.
• W1979566467 cites W1483624903 @default.
• W1979566467 cites W1491042842 @default.
• W1979566467 cites W1494239480 @default.
• W1979566467 cites W150246076 @default.
• W1979566467 cites W1542263802 @default.
• W1979566467 cites W1551064372 @default.
• W1979566467 cites W1559795048 @default.
• W1979566467 cites W1569503463 @default.
• W1979566467 cites W1585306115 @default.
• W1979566467 cites W1589002191 @default.
• W1979566467 cites W1598726068 @default.
• W1979566467 cites W1625124567 @default.
• W1979566467 cites W1650401181 @default.
• W1979566467 cites W1672764189 @default.
• W1979566467 cites W170591362 @default.
• W1979566467 cites W1741265558 @default.
• W1979566467 cites W1920479129 @default.
• W1979566467 cites W193006127 @default.
• W1979566467 cites W1957111431 @default.
• W1979566467 cites W1959238069 @default.
• W1979566467 cites W1963611129 @default.
• W1979566467 cites W1963791094 @default.
• W1979566467 cites W1964442923 @default.
• W1979566467 cites W1965893090 @default.
• W1979566467 cites W1966795480 @default.
• W1979566467 cites W1968540123 @default.
• W1979566467 cites W1968789295 @default.
• W1979566467 cites W1969914617 @default.
• W1979566467 cites W1971042658 @default.
• W1979566467 cites W1971510102 @default.
• W1979566467 cites W1974642741 @default.
• W1979566467 cites W1974763427 @default.
• W1979566467 cites W1975551623 @default.
• W1979566467 cites W1975700762 @default.
• W1979566467 cites W1976456842 @default.
• W1979566467 cites W1980726951 @default.
• W1979566467 cites W1980997572 @default.
• W1979566467 cites W1981075941 @default.
• W1979566467 cites W1981582810 @default.
• W1979566467 cites W1982212676 @default.
• W1979566467 cites W1982422775 @default.
• W1979566467 cites W1983659533 @default.
• W1979566467 cites W1983820222 @default.
• W1979566467 cites W1983820893 @default.
• W1979566467 cites W1984482377 @default.
• W1979566467 cites W1985134966 @default.
• W1979566467 cites W1985231626 @default.
• W1979566467 cites W1986594434 @default.
• W1979566467 cites W1992814187 @default.
• W1979566467 cites W1993088121 @default.
• W1979566467 cites W1996744375 @default.
• W1979566467 cites W1998790904 @default.
• W1979566467 cites W1999058821 @default.
• W1979566467 cites W1999344800 @default.
• W1979566467 cites W1999855702 @default.
• W1979566467 cites W2000200809 @default.
• W1979566467 cites W2002461308 @default.
• W1979566467 cites W2003653107 @default.
• W1979566467 cites W2004540956 @default.
• W1979566467 cites W2007202933 @default.
• W1979566467 cites W2008479138 @default.
• W1979566467 cites W2009301053 @default.
• W1979566467 cites W2009777952 @default.
• W1979566467 cites W2013151879 @default.
• W1979566467 cites W2015594876 @default.
• W1979566467 cites W2016479661 @default.
• W1979566467 cites W2016944692 @default.
• W1979566467 cites W2018800923 @default.
• W1979566467 cites W2019904725 @default.
• W1979566467 cites W2020886088 @default.
• W1979566467 cites W2023874952 @default.
• W1979566467 cites W2025508492 @default.
• W1979566467 cites W2025596955 @default.
• W1979566467 cites W2026420920 @default.
• W1979566467 cites W2026770951 @default.
• W1979566467 cites W2031583642 @default.
• W1979566467 cites W2032781637 @default.
• W1979566467 cites W2034862605 @default.
• W1979566467 cites W2034998738 @default.
• W1979566467 cites W2036509457 @default.
• W1979566467 cites W2040352872 @default.
• W1979566467 cites W2040618621 @default.
• W1979566467 cites W2041187778 @default.
• W1979566467 cites W2042415707 @default.
• W1979566467 cites W2043951488 @default.
• W1979566467 cites W2046016490 @default.
• W1979566467 cites W2046196975 @default.

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