FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979585536> ?p ?o ?g. }

• W1979585536 endingPage "215" @default.
• W1979585536 startingPage "206" @default.
• W1979585536 abstract "Objective Recent advances in gene expression technology have provided insights into global messenger RNA (mRNA) expression changes associated with endometrial cancer development. However, the post-transcriptional events that may also have phenotypic consequences remain to be completely delineated. MicroRNAs (miRNAs) are small non-coding RNA transcripts, that influence cell function via modulation of post-transcriptional activity of multiple target mRNA genes. Although recent reports suggest that miRNAs may influence human cancer development, their role in endometrial carcinogenesis remains to be described. Methods We measured expression of 335 unique human miRNAs in 61 fresh-frozen endometrial specimens, including 37 endometrial cancers, 20 normal endometrium, and 4 complex atypical hyperplasia samples. In parallel, expression of 22,000 mRNA genes was analyzed using the Affymetrix Human U133A GeneChips in 29 of the endometrial samples, including 20 endometrial carcinomas and 9 normal endometrial samples. Differentially expressed mRNAs, miRNAs, and predicted miRNA–mRNA targets were integrated and evaluated for representation of relevant functional biologic pathways. Results Thirteen miRNAs (p<0.02) and 90 mRNAs (FDR; 0%) were identified to be associated with endometrial cancer development. Twenty-six of the 90 (29%) differentially expressed mRNAs are Sangar-database predicted mRNA targets of the 13 miRNAs. Pathway analysis demonstrates significant involvement of these 26 mRNA genes in processes including cell death, growth, proliferation, and carcinogenesis. Conclusion We have identified miRNAs and mRNAs associated with endometrial cancer development. Further, our strategy of integrating miRNA/mRNA data may also aid in the identification of important biologic pathways and additional unique genes that have importance in endometrial pathogenesis." @default.
• W1979585536 created "2016-06-24" @default.
• W1979585536 creator A5000451156 @default.
• W1979585536 creator A5006894236 @default.
• W1979585536 creator A5016350597 @default.
• W1979585536 creator A5037157904 @default.
• W1979585536 creator A5044655732 @default.
• W1979585536 creator A5045131302 @default.
• W1979585536 creator A5050753481 @default.
• W1979585536 creator A5057494906 @default.
• W1979585536 creator A5067734124 @default.
• W1979585536 creator A5083064982 @default.
• W1979585536 date "2008-08-01" @default.
• W1979585536 modified "2023-10-17" @default.
• W1979585536 title "MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis" @default.
• W1979585536 cites W144423133 @default.
• W1979585536 cites W1583065916 @default.
• W1979585536 cites W1965769128 @default.
• W1979585536 cites W1966686742 @default.
• W1979585536 cites W1979652171 @default.
• W1979585536 cites W1981721183 @default.
• W1979585536 cites W1984584032 @default.
• W1979585536 cites W1987286138 @default.
• W1979585536 cites W1996127971 @default.
• W1979585536 cites W1997491084 @default.
• W1979585536 cites W2006797972 @default.
• W1979585536 cites W2024273611 @default.
• W1979585536 cites W2028773225 @default.
• W1979585536 cites W2036169252 @default.
• W1979585536 cites W2062290101 @default.
• W1979585536 cites W2064331438 @default.
• W1979585536 cites W2064651108 @default.
• W1979585536 cites W2081452698 @default.
• W1979585536 cites W2084894426 @default.
• W1979585536 cites W2092868756 @default.
• W1979585536 cites W2101083650 @default.
• W1979585536 cites W2112192177 @default.
• W1979585536 cites W2120639213 @default.
• W1979585536 cites W2130979840 @default.
• W1979585536 cites W2135810600 @default.
• W1979585536 cites W2135836598 @default.
• W1979585536 cites W2139930644 @default.
• W1979585536 cites W2144805161 @default.
• W1979585536 cites W2144947440 @default.
• W1979585536 cites W2157216556 @default.
• W1979585536 cites W2394593050 @default.
• W1979585536 cites W2910065277 @default.
• W1979585536 doi "https://doi.org/10.1016/j.ygyno.2008.03.023" @default.
• W1979585536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18499237" @default.
• W1979585536 hasPublicationYear "2008" @default.
• W1979585536 type Work @default.
• W1979585536 sameAs 1979585536 @default.
• W1979585536 citedByCount "151" @default.
• W1979585536 countsByYear W19795855362012 @default.
• W1979585536 countsByYear W19795855362013 @default.
• W1979585536 countsByYear W19795855362014 @default.
• W1979585536 countsByYear W19795855362015 @default.
• W1979585536 countsByYear W19795855362016 @default.
• W1979585536 countsByYear W19795855362017 @default.
• W1979585536 countsByYear W19795855362018 @default.
• W1979585536 countsByYear W19795855362019 @default.
• W1979585536 countsByYear W19795855362020 @default.
• W1979585536 countsByYear W19795855362021 @default.
• W1979585536 countsByYear W19795855362022 @default.
• W1979585536 countsByYear W19795855362023 @default.
• W1979585536 crossrefType "journal-article" @default.
• W1979585536 hasAuthorship W1979585536A5000451156 @default.
• W1979585536 hasAuthorship W1979585536A5006894236 @default.
• W1979585536 hasAuthorship W1979585536A5016350597 @default.
• W1979585536 hasAuthorship W1979585536A5037157904 @default.
• W1979585536 hasAuthorship W1979585536A5044655732 @default.
• W1979585536 hasAuthorship W1979585536A5045131302 @default.
• W1979585536 hasAuthorship W1979585536A5050753481 @default.
• W1979585536 hasAuthorship W1979585536A5057494906 @default.
• W1979585536 hasAuthorship W1979585536A5067734124 @default.
• W1979585536 hasAuthorship W1979585536A5083064982 @default.
• W1979585536 hasConcept C104317684 @default.
• W1979585536 hasConcept C105580179 @default.
• W1979585536 hasConcept C121608353 @default.
• W1979585536 hasConcept C145059251 @default.
• W1979585536 hasConcept C150194340 @default.
• W1979585536 hasConcept C162317418 @default.
• W1979585536 hasConcept C165864922 @default.
• W1979585536 hasConcept C2777088508 @default.
• W1979585536 hasConcept C502942594 @default.
• W1979585536 hasConcept C54355233 @default.
• W1979585536 hasConcept C555283112 @default.
• W1979585536 hasConcept C67705224 @default.
• W1979585536 hasConcept C86803240 @default.
• W1979585536 hasConceptScore W1979585536C104317684 @default.
• W1979585536 hasConceptScore W1979585536C105580179 @default.
• W1979585536 hasConceptScore W1979585536C121608353 @default.
• W1979585536 hasConceptScore W1979585536C145059251 @default.
• W1979585536 hasConceptScore W1979585536C150194340 @default.
• W1979585536 hasConceptScore W1979585536C162317418 @default.
• W1979585536 hasConceptScore W1979585536C165864922 @default.
• W1979585536 hasConceptScore W1979585536C2777088508 @default.
• W1979585536 hasConceptScore W1979585536C502942594 @default.

• next