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- W1979588422 abstract "Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate. See research article: http://www.biomedcentral.com/1741-7007/8/72/" @default.
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- W1979588422 date "2010-07-19" @default.
- W1979588422 modified "2023-10-16" @default.
- W1979588422 title "Regulation of lipid droplet turnover by ubiquitin ligases" @default.
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- W1979588422 doi "https://doi.org/10.1186/1741-7007-8-94" @default.
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