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• W1979588857 abstract "A taxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA double-strand break (DSB) response. We recently showed that transcription-blocking topoisomerase I cleavage complexes (TOP1cc) produce DSBs related to R-loop formation and activate ATM in post-mitotic neurons and lymphocytes. Here we discuss how TOP1cc can produce transcription arrest with R-loop formation and generate DSBs that activate ATM, as well as data suggesting that those transcription-dependent DSBs tend to form at the IgH locus and at specific genomic sites. We also address the potential roles of ATM in response to transcription-blocking TOP1cc." @default.
• W1979588857 created "2016-06-24" @default.
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• W1979588857 date "2010-01-15" @default.
• W1979588857 modified "2023-10-16" @default.
• W1979588857 title "DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions" @default.
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• W1979588857 doi "https://doi.org/10.4161/cc.9.2.10506" @default.
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