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- W1979589970 abstract "Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled Osteoarthritis." @default.
- W1979589970 created "2016-06-24" @default.
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- W1979589970 date "2012-08-01" @default.
- W1979589970 modified "2023-10-02" @default.
- W1979589970 title "Pathophysiology of peri-articular bone changes in osteoarthritis" @default.
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- W1979589970 doi "https://doi.org/10.1016/j.bone.2012.02.002" @default.
- W1979589970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22343134" @default.
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