Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979601919> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1979601919 endingPage "330" @default.
- W1979601919 startingPage "325" @default.
- W1979601919 abstract "Prostaglandin (PG) E1 has been shown to improve thromboresistance. This experiment was designed to examine whether an effect on the arterial wall or the platelets is responsible for this phenomenon. Using a cross-perfusion model, the aortic and iliac artery endothelium of rabbits was removed by a balloon catheter before being perfused with blood of donor rabbits. Donor and/or receiver animals were treated with 20 microg PGE1 or vehicle (cyclodextrin) intravenously daily for 1 week. After the last administration of PGE1 or its vehicle, the animals were killed and native blood from a donor rabbit was recirculated (30 ml/min) via a deendothelialized segment of a receiver rabbit. The contact (C) and spread (S) platelets as well as the denuded surface covered with platelet aggregates (> 5 microm in height) were quantified by morphometry. Deposition of (111)In-oxine labeled autologous platelets was quantitatively determined per surface unit. In addition, PGI(2)- and TXB2-formation by the denuded aortic and iliac artery segments was determined. Pretreatment of receiver rabbits with PGE1 resulted in morphometrically assessed decreased platelet adhesion and aggregation, even when the donor rabbit was vehicle-treated. A vehicle-treated receiver rabbit, in contrast, shows platelet deposition comparable to controls, even if the donor rabbit was PGE1-pretreated. Treatment of donor animals with PGE1 did not result in a reduction in thrombogenicity. The beneficial in vivo PGE1 action of decreased arterial thrombogenicity is thus mediated by an effect on the vascular wall rather than on circulating platelets." @default.
- W1979601919 created "2016-06-24" @default.
- W1979601919 creator A5031802447 @default.
- W1979601919 creator A5041319996 @default.
- W1979601919 creator A5060698136 @default.
- W1979601919 creator A5080725449 @default.
- W1979601919 creator A5090511903 @default.
- W1979601919 date "1997-04-01" @default.
- W1979601919 modified "2023-10-16" @default.
- W1979601919 title "PGE1-induced arterial thromboresistance is a vascular property as identified by cross-perfusion technique" @default.
- W1979601919 cites W1496176397 @default.
- W1979601919 cites W1599055297 @default.
- W1979601919 cites W1967225427 @default.
- W1979601919 cites W1971317676 @default.
- W1979601919 cites W1986197498 @default.
- W1979601919 cites W1996454982 @default.
- W1979601919 cites W2006980585 @default.
- W1979601919 cites W2013123441 @default.
- W1979601919 cites W2020747730 @default.
- W1979601919 cites W2021403302 @default.
- W1979601919 cites W2032575272 @default.
- W1979601919 cites W2032976089 @default.
- W1979601919 cites W2037927096 @default.
- W1979601919 cites W2040636246 @default.
- W1979601919 cites W2062858964 @default.
- W1979601919 cites W2080968453 @default.
- W1979601919 cites W2135561263 @default.
- W1979601919 cites W2142339759 @default.
- W1979601919 cites W2394690009 @default.
- W1979601919 cites W2401171451 @default.
- W1979601919 cites W2409491778 @default.
- W1979601919 cites W341728578 @default.
- W1979601919 doi "https://doi.org/10.1016/s0952-3278(97)90577-9" @default.
- W1979601919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9150379" @default.
- W1979601919 hasPublicationYear "1997" @default.
- W1979601919 type Work @default.
- W1979601919 sameAs 1979601919 @default.
- W1979601919 citedByCount "4" @default.
- W1979601919 crossrefType "journal-article" @default.
- W1979601919 hasAuthorship W1979601919A5031802447 @default.
- W1979601919 hasAuthorship W1979601919A5041319996 @default.
- W1979601919 hasAuthorship W1979601919A5060698136 @default.
- W1979601919 hasAuthorship W1979601919A5080725449 @default.
- W1979601919 hasAuthorship W1979601919A5090511903 @default.
- W1979601919 hasConcept C126322002 @default.
- W1979601919 hasConcept C139059822 @default.
- W1979601919 hasConcept C146957229 @default.
- W1979601919 hasConcept C150903083 @default.
- W1979601919 hasConcept C185592680 @default.
- W1979601919 hasConcept C207001950 @default.
- W1979601919 hasConcept C2776649359 @default.
- W1979601919 hasConcept C2776820930 @default.
- W1979601919 hasConcept C2777736543 @default.
- W1979601919 hasConcept C2778506911 @default.
- W1979601919 hasConcept C2779133491 @default.
- W1979601919 hasConcept C2779837120 @default.
- W1979601919 hasConcept C2993470428 @default.
- W1979601919 hasConcept C71924100 @default.
- W1979601919 hasConcept C86803240 @default.
- W1979601919 hasConcept C89560881 @default.
- W1979601919 hasConceptScore W1979601919C126322002 @default.
- W1979601919 hasConceptScore W1979601919C139059822 @default.
- W1979601919 hasConceptScore W1979601919C146957229 @default.
- W1979601919 hasConceptScore W1979601919C150903083 @default.
- W1979601919 hasConceptScore W1979601919C185592680 @default.
- W1979601919 hasConceptScore W1979601919C207001950 @default.
- W1979601919 hasConceptScore W1979601919C2776649359 @default.
- W1979601919 hasConceptScore W1979601919C2776820930 @default.
- W1979601919 hasConceptScore W1979601919C2777736543 @default.
- W1979601919 hasConceptScore W1979601919C2778506911 @default.
- W1979601919 hasConceptScore W1979601919C2779133491 @default.
- W1979601919 hasConceptScore W1979601919C2779837120 @default.
- W1979601919 hasConceptScore W1979601919C2993470428 @default.
- W1979601919 hasConceptScore W1979601919C71924100 @default.
- W1979601919 hasConceptScore W1979601919C86803240 @default.
- W1979601919 hasConceptScore W1979601919C89560881 @default.
- W1979601919 hasIssue "4" @default.
- W1979601919 hasLocation W19796019191 @default.
- W1979601919 hasLocation W19796019192 @default.
- W1979601919 hasOpenAccess W1979601919 @default.
- W1979601919 hasPrimaryLocation W19796019191 @default.
- W1979601919 hasRelatedWork W1144120039 @default.
- W1979601919 hasRelatedWork W1964723030 @default.
- W1979601919 hasRelatedWork W1979601919 @default.
- W1979601919 hasRelatedWork W2009449552 @default.
- W1979601919 hasRelatedWork W2039059655 @default.
- W1979601919 hasRelatedWork W2056553455 @default.
- W1979601919 hasRelatedWork W2059575373 @default.
- W1979601919 hasRelatedWork W2409355185 @default.
- W1979601919 hasRelatedWork W4296244080 @default.
- W1979601919 hasRelatedWork W3031396723 @default.
- W1979601919 hasVolume "56" @default.
- W1979601919 isParatext "false" @default.
- W1979601919 isRetracted "false" @default.
- W1979601919 magId "1979601919" @default.
- W1979601919 workType "article" @default.