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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979613025> ?p ?o ?g. }

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• W1979613025 abstract "Organ transplant recipients who have dyslipidemia related to immunosuppression may benefit from cholesterol-lowering therapy with ezetimibe, a substrate of ABCB1, ABCC2, and OATP1B1. Adverse pharmacokinetic interactions are hypothesized with sirolimus, which is a substrate of OATP1B1 and OATP1B3 and an inhibitor of ABCB1, OATP1B1, and OATP1B3 but not of ABCC2. However, competition between sirolimus and ezetimibe for ABCB1 and OATP1B1 is not of major clinical relevance, as confirmed in our randomized, controlled, single-dose study in healthy subjects. Clinical Pharmacology & Therapeutics (2010) 87 6, 663–667. doi: 10.1038/clpt.2009.266" @default.
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• W1979613025 date "2010-03-10" @default.
• W1979613025 modified "2023-10-16" @default.
• W1979613025 title "Pharmacokinetic and Pharmacodynamic Interactions Between the Immunosuppressant Sirolimus and the Lipid-Lowering Drug Ezetimibe in Healthy Volunteers" @default.
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• W1979613025 doi "https://doi.org/10.1038/clpt.2009.266" @default.
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