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- W1979636524 abstract "has two parts; easier “Off” and a difficult “On” state. Time required to complete both parts, OffTime+OnTime, determines impairment. Aim: To define normative values for EncephalApp and perform sensitivity analyses of the MHE diagnosis in a multi-center US study. Methods: Age-matched healthy controls from three sites (Virginia/ Arkansas/Ohio) and outpatient cirrhotics (Virginia/Ohio) were administered the gold standard (PHES, psychometric hepatic encephalopathy score: 6 tests) and EncephalApp. Results impaired >−4SD than controls was deemed MHE on PHES as recommended while 2SD beyond controls on OffTime+OnTime was considered impaired on EncephalApp. Concordance between sites regarding EncephalApp cut-offs and PHES diagnosis of MHE was performed using Kappa. Sensitivity/specificity of EncephalApp cut-offs compared to PHES was calculated as a whole and in each center using ROC. Results: 134 controls (56 Virginia, 50 Ohio, 28 Arkansas, age 55±7yrs, education 14±2.5 yrs) and 176 cirrhotics (137 Virginia, 39 Ohio, 57±4yrs, education 13±2yrs) were included. Based on control+2SD OffTime+OnTime, EncephalApp cut-offs were 206 seconds for all controls, 202 using Virginia controls only, 211 for Arkansas controls and 209 seconds for Ohio controls only. There was a high concordance of abnormal EncephalApp between these 3 sites (Kappa range 0.80–0.90, Table). The specificity/sensitivity were 81% using PHES as the gold standard at 183 seconds cut-off with AUC of 0.90." @default.
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- W1979636524 date "2014-04-01" @default.
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- W1979636524 title "P459 RESCUE THERAPY BY AUTOLOGOUS INFUSION OF GRANULOCYTE-COLONY STIMULATING FACTOR-MOBILIZED PERIPHERAL BLOOD CD34-POSITIVE CELLS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS" @default.
- W1979636524 doi "https://doi.org/10.1016/s0168-8278(14)60621-8" @default.
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