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- W1979636623 abstract "Objectives To test the hypothesis that, in newborn piglets, the presence of a tension pneumothorax modifies the cardiovascular responses to hypoxia/hypercarbia. Design Prospective laboratory study. Setting Perinatal cardiovascular research laboratory at a university school of medicine. Subjects Seven newborn piglets. Interventions We sequentially exposed the piglets to a baseline (control I) measure, hypoxia/hypercarbia, tension pneumothorax with normoxia/normocarbia, and tension pneumothorax with hypoxia/hypercarbia added. Measurements and Main Results Brain and systemic blood pressures and blood flow (radionuclide-microspheres) were measured. Hypoxia/hypercarbia resulted in increased brain perfusion (207 ± 61% of control, mean ± SEM, p < .05) and heart perfusion (176 ± 58% of control, p < .05) and decreased gastrointestinal perfusion (-37 ± 9% of control, p < .05). Tension pneumothorax with normoxia/normocarbia reduced the cardiac output (-70 ± 8% of control, p < .05), which was redistributed toward the brain (p < .05) at the expense of the gastrointestinal tract (p < .05). Although this redistribution in cardiac output persisted during tension pneumothorax with hypoxia/hypercarbia added, sustained reductions in cardiac output (-57 ± 11%, of control, p < .01) were associated with smaller increases in perfusion to brain (55 ± 54 vs. 207 ± 61% of control, tension pneumothorax with hypoxia/hypercarbia added, and hypoxia/hypercarbia time periods, respectively, p < .05) and heart (65 ± 49 vs. 176 ± 58% of control, tension pneumothorax with hypoxia/hypercarbia added, and hypoxia/hypercarbia time periods, respectively, p < .05) and larger decreases in blood flow to gastrointestinal tract, pancreas, and kidneys (p < .05) than with hypoxia/hypercarbia alone. Conclusions Tension pneumothorax-induced reductions in cardiac output limit the hypoxia/hypercarbia-mediated increases in perfusion to brain and heart and accentuate the hypoxia/hypercarbia-related decreases in perfusion to kidneys and splanchnic organs. (Crit Care Med 1994; 22:1453–1460)" @default.
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- W1979636623 date "1994-09-01" @default.
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- W1979636623 title "Cardiovascular effects of hypoxia/hypercarbia and tension pneumothorax in newborn piglets" @default.
- W1979636623 doi "https://doi.org/10.1097/00003246-199409000-00016" @default.
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