Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979647427> ?p ?o ?g. }
- W1979647427 endingPage "1590" @default.
- W1979647427 startingPage "1581" @default.
- W1979647427 abstract "To determine the role of STAT3 in adipose tissue, we used Cre-loxP DNA recombination to create mice with an adipocyte-specific disruption of the STAT3 gene (ASKO mice). aP2-Cre-driven disappearance of STAT3 expression occurred on d 6 of adipogenesis, a time point when preadipocytes have already undergone conversion to adipocytes. Thus, this knockout model examined the role of STAT3 in mature but not differentiating adipocytes. Beginning at 9 wk of age, ASKO mice weighed more than their littermate controls and had increased adipose tissue mass, associated with adipocyte hypertrophy, but not adipocyte hyperplasia, hyperphagia, or reduced energy expenditure. Leptin-induced, but not isoproterenol-induced, lipolysis was impaired in ASKO adipocytes, which may partially explain the increased cell size. Despite reduced adiponectin and increased liver triacylglycerol, ASKO mice displayed normal glucose tolerance. Overall, these findings demonstrate that adipocyte STAT3 regulates body weight homeostasis in part through direct effects of leptin on adipocytes." @default.
- W1979647427 created "2016-06-24" @default.
- W1979647427 creator A5035652921 @default.
- W1979647427 creator A5049827455 @default.
- W1979647427 creator A5050012538 @default.
- W1979647427 creator A5053314060 @default.
- W1979647427 creator A5055643812 @default.
- W1979647427 date "2007-12-20" @default.
- W1979647427 modified "2023-09-29" @default.
- W1979647427 title "Adipose-Specific Disruption of Signal Transducer and Activator of Transcription 3 Increases Body Weight and Adiposity" @default.
- W1979647427 cites W1502152603 @default.
- W1979647427 cites W1631449371 @default.
- W1979647427 cites W1967078210 @default.
- W1979647427 cites W1967466043 @default.
- W1979647427 cites W1975388439 @default.
- W1979647427 cites W1981261500 @default.
- W1979647427 cites W1981799488 @default.
- W1979647427 cites W1982659014 @default.
- W1979647427 cites W1993102144 @default.
- W1979647427 cites W1995000970 @default.
- W1979647427 cites W2001141741 @default.
- W1979647427 cites W2002165978 @default.
- W1979647427 cites W2004861205 @default.
- W1979647427 cites W2012898950 @default.
- W1979647427 cites W2020971663 @default.
- W1979647427 cites W2021895570 @default.
- W1979647427 cites W2024802365 @default.
- W1979647427 cites W2043106623 @default.
- W1979647427 cites W2053965920 @default.
- W1979647427 cites W2059992589 @default.
- W1979647427 cites W2060952287 @default.
- W1979647427 cites W2066243203 @default.
- W1979647427 cites W2080649034 @default.
- W1979647427 cites W2089582261 @default.
- W1979647427 cites W2091759162 @default.
- W1979647427 cites W2094823144 @default.
- W1979647427 cites W2098303506 @default.
- W1979647427 cites W2102470568 @default.
- W1979647427 cites W2102826750 @default.
- W1979647427 cites W2104668978 @default.
- W1979647427 cites W2104986849 @default.
- W1979647427 cites W2108046132 @default.
- W1979647427 cites W2108916652 @default.
- W1979647427 cites W2109421395 @default.
- W1979647427 cites W2112857693 @default.
- W1979647427 cites W2115630287 @default.
- W1979647427 cites W2120282127 @default.
- W1979647427 cites W2122726077 @default.
- W1979647427 cites W2124038922 @default.
- W1979647427 cites W2133032991 @default.
- W1979647427 cites W2143873575 @default.
- W1979647427 cites W2146007589 @default.
- W1979647427 cites W2157843109 @default.
- W1979647427 cites W2161944247 @default.
- W1979647427 cites W2164015929 @default.
- W1979647427 cites W2167335894 @default.
- W1979647427 cites W2168526937 @default.
- W1979647427 cites W2170404804 @default.
- W1979647427 cites W2171952619 @default.
- W1979647427 cites W2172238082 @default.
- W1979647427 cites W2615637571 @default.
- W1979647427 cites W4237813261 @default.
- W1979647427 doi "https://doi.org/10.1210/en.2007-1148" @default.
- W1979647427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2276706" @default.
- W1979647427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18096662" @default.
- W1979647427 hasPublicationYear "2007" @default.
- W1979647427 type Work @default.
- W1979647427 sameAs 1979647427 @default.
- W1979647427 citedByCount "77" @default.
- W1979647427 countsByYear W19796474272012 @default.
- W1979647427 countsByYear W19796474272013 @default.
- W1979647427 countsByYear W19796474272014 @default.
- W1979647427 countsByYear W19796474272015 @default.
- W1979647427 countsByYear W19796474272016 @default.
- W1979647427 countsByYear W19796474272017 @default.
- W1979647427 countsByYear W19796474272018 @default.
- W1979647427 countsByYear W19796474272019 @default.
- W1979647427 countsByYear W19796474272020 @default.
- W1979647427 countsByYear W19796474272021 @default.
- W1979647427 countsByYear W19796474272022 @default.
- W1979647427 countsByYear W19796474272023 @default.
- W1979647427 crossrefType "journal-article" @default.
- W1979647427 hasAuthorship W1979647427A5035652921 @default.
- W1979647427 hasAuthorship W1979647427A5049827455 @default.
- W1979647427 hasAuthorship W1979647427A5050012538 @default.
- W1979647427 hasAuthorship W1979647427A5053314060 @default.
- W1979647427 hasAuthorship W1979647427A5055643812 @default.
- W1979647427 hasBestOaLocation W19796474271 @default.
- W1979647427 hasConcept C122927707 @default.
- W1979647427 hasConcept C126322002 @default.
- W1979647427 hasConcept C134018914 @default.
- W1979647427 hasConcept C140985366 @default.
- W1979647427 hasConcept C151955695 @default.
- W1979647427 hasConcept C171089720 @default.
- W1979647427 hasConcept C185592680 @default.
- W1979647427 hasConcept C194832188 @default.
- W1979647427 hasConcept C2491326 @default.
- W1979647427 hasConcept C2776175234 @default.