Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979652807> ?p ?o ?g. }
- W1979652807 endingPage "69" @default.
- W1979652807 startingPage "56" @default.
- W1979652807 abstract "Aiming to contribute toward the characterization of new, biotechnologically relevant cellulolytic enzymes, we report here the first crystal structure of the catalytic core domain of Cel7A (cellobiohydrolase I) from the filamentous fungus Trichoderma harzianum IOC 3844. Our structural studies and molecular dynamics simulations show that the flexibility of Tyr260, in comparison with Tyr247 from the homologous Trichoderma reesei Cel7A, is enhanced as a result of the short side-chains of adjacent Val216 and Ala384 residues and creates an additional gap at the side face of the catalytic tunnel. T. harzianum cellobiohydrolase I also has a shortened loop at the entrance of the cellulose-binding tunnel, which has been described to interact with the substrate in T. reesei Cel7A. These structural features might explain why T. harzianum Cel7A displays higher kcat and Km values, and lower product inhibition on both glucoside and lactoside substrates, compared with T. reesei Cel7A." @default.
- W1979652807 created "2016-06-24" @default.
- W1979652807 creator A5006609469 @default.
- W1979652807 creator A5009081750 @default.
- W1979652807 creator A5022831131 @default.
- W1979652807 creator A5027017783 @default.
- W1979652807 creator A5043609909 @default.
- W1979652807 creator A5056003396 @default.
- W1979652807 creator A5058419271 @default.
- W1979652807 creator A5072069815 @default.
- W1979652807 creator A5077460651 @default.
- W1979652807 creator A5078225434 @default.
- W1979652807 date "2012-11-29" @default.
- W1979652807 modified "2023-10-03" @default.
- W1979652807 title "Joint X-ray crystallographic and molecular dynamics study of cellobiohydrolase I from<i>Trichoderma harzianum</i>: deciphering the structural features of cellobiohydrolase catalytic activity" @default.
- W1979652807 cites W1504946493 @default.
- W1979652807 cites W1539796472 @default.
- W1979652807 cites W1590992295 @default.
- W1979652807 cites W1836519219 @default.
- W1979652807 cites W1907236681 @default.
- W1979652807 cites W1935712031 @default.
- W1979652807 cites W1964983951 @default.
- W1979652807 cites W1966642263 @default.
- W1979652807 cites W1970456511 @default.
- W1979652807 cites W1976499671 @default.
- W1979652807 cites W1977258922 @default.
- W1979652807 cites W1981803179 @default.
- W1979652807 cites W1985447246 @default.
- W1979652807 cites W1993248690 @default.
- W1979652807 cites W2001384967 @default.
- W1979652807 cites W2003949305 @default.
- W1979652807 cites W2007813796 @default.
- W1979652807 cites W2013721896 @default.
- W1979652807 cites W2014757220 @default.
- W1979652807 cites W2016765195 @default.
- W1979652807 cites W2019810991 @default.
- W1979652807 cites W2023692527 @default.
- W1979652807 cites W2025258264 @default.
- W1979652807 cites W2027408247 @default.
- W1979652807 cites W2029381257 @default.
- W1979652807 cites W2033057757 @default.
- W1979652807 cites W2038770548 @default.
- W1979652807 cites W2046017287 @default.
- W1979652807 cites W2046372871 @default.
- W1979652807 cites W2046769757 @default.
- W1979652807 cites W2048476205 @default.
- W1979652807 cites W2051921179 @default.
- W1979652807 cites W2059025873 @default.
- W1979652807 cites W2059547154 @default.
- W1979652807 cites W2060556113 @default.
- W1979652807 cites W2060811229 @default.
- W1979652807 cites W2063437430 @default.
- W1979652807 cites W2064902795 @default.
- W1979652807 cites W2065062309 @default.
- W1979652807 cites W2065497396 @default.
- W1979652807 cites W2067174909 @default.
- W1979652807 cites W2077005247 @default.
- W1979652807 cites W2077143061 @default.
- W1979652807 cites W2077634463 @default.
- W1979652807 cites W2086114813 @default.
- W1979652807 cites W2088076972 @default.
- W1979652807 cites W2096335011 @default.
- W1979652807 cites W2103711007 @default.
- W1979652807 cites W2103905846 @default.
- W1979652807 cites W2113876854 @default.
- W1979652807 cites W2117458899 @default.
- W1979652807 cites W2118455767 @default.
- W1979652807 cites W2119336221 @default.
- W1979652807 cites W2122339645 @default.
- W1979652807 cites W2124698238 @default.
- W1979652807 cites W2136834927 @default.
- W1979652807 cites W2144081223 @default.
- W1979652807 cites W2147508889 @default.
- W1979652807 cites W2150981663 @default.
- W1979652807 cites W2154965211 @default.
- W1979652807 cites W2160360844 @default.
- W1979652807 cites W2161866943 @default.
- W1979652807 cites W2180229411 @default.
- W1979652807 cites W4241379108 @default.
- W1979652807 doi "https://doi.org/10.1111/febs.12049" @default.
- W1979652807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23114223" @default.
- W1979652807 hasPublicationYear "2012" @default.
- W1979652807 type Work @default.
- W1979652807 sameAs 1979652807 @default.
- W1979652807 citedByCount "43" @default.
- W1979652807 countsByYear W19796528072013 @default.
- W1979652807 countsByYear W19796528072014 @default.
- W1979652807 countsByYear W19796528072015 @default.
- W1979652807 countsByYear W19796528072016 @default.
- W1979652807 countsByYear W19796528072017 @default.
- W1979652807 countsByYear W19796528072018 @default.
- W1979652807 countsByYear W19796528072019 @default.
- W1979652807 countsByYear W19796528072020 @default.
- W1979652807 countsByYear W19796528072021 @default.
- W1979652807 countsByYear W19796528072022 @default.
- W1979652807 countsByYear W19796528072023 @default.
- W1979652807 crossrefType "journal-article" @default.
- W1979652807 hasAuthorship W1979652807A5006609469 @default.