Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979657178> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1979657178 endingPage "2638" @default.
- W1979657178 startingPage "2633" @default.
- W1979657178 abstract "The renal glycoprotein hormone erythropoietin (Epo) interacts with erythrocytic progenitors to stimulate their proliferation and differentiation in the bone marrow. The renal O2-sensing mechanism in the control of the synthesis of Epo is still poorly understood. Therefore, the capacity of isolated rat kidneys to produce Epo during hypoxic and anemic perfusion was studied. The kidneys were perfused at a constant perfusion pressure of 100 mm Hg with a substrate-enriched Krebs-Henseleit solution containing 60 g/liter BSA and freshly drawn human erythrocytes. Epo was measured by RIA. When the kidneys were perfused at an arterial pO2 of 720 or 150 mm Hg (hematocrit, 5%), Epo production was very low (0.1-0.2 U/g kidney within 3 h of perfusion). When the arterial pO2 was lowered to 35 or 20 mm Hg, Epo production increased to 0.4 and 0.9 U/g kidney, respectively. The release of Epo during hypoxic perfusion (pO2 35 and 20 mm Hg) was little affected by changes in the hematocrit, i.e. the O2-carrying capacity of the perfusion medium over a wide range (0-40%). These results indicate that the production of Epo in the isolated perfused kidney depends on the availability of O2 and can be modulated by changes in the arterial pO2. (Endocrinology128: 2633–2638, 1991)" @default.
- W1979657178 created "2016-06-24" @default.
- W1979657178 creator A5005625193 @default.
- W1979657178 creator A5020437320 @default.
- W1979657178 creator A5016647678 @default.
- W1979657178 date "1991-05-01" @default.
- W1979657178 modified "2023-10-18" @default.
- W1979657178 title "Isolated Serum-Free Perfused Rat Kidneys Release Immunoreactive Erythropoietin in Response to Hypoxia*" @default.
- W1979657178 cites W1277647379 @default.
- W1979657178 cites W140300158 @default.
- W1979657178 cites W170969310 @default.
- W1979657178 cites W180259371 @default.
- W1979657178 cites W2009134328 @default.
- W1979657178 cites W2026433951 @default.
- W1979657178 cites W2045566612 @default.
- W1979657178 cites W2049634503 @default.
- W1979657178 cites W2053827071 @default.
- W1979657178 cites W2059468530 @default.
- W1979657178 cites W2060357691 @default.
- W1979657178 cites W2074610002 @default.
- W1979657178 cites W2083268019 @default.
- W1979657178 cites W2086298777 @default.
- W1979657178 cites W2095238820 @default.
- W1979657178 cites W2101911460 @default.
- W1979657178 cites W2132836753 @default.
- W1979657178 cites W214360211 @default.
- W1979657178 cites W2145942173 @default.
- W1979657178 cites W2258272797 @default.
- W1979657178 cites W2260272327 @default.
- W1979657178 cites W2296796125 @default.
- W1979657178 cites W2405329144 @default.
- W1979657178 cites W2408175268 @default.
- W1979657178 cites W2411445429 @default.
- W1979657178 cites W2418451240 @default.
- W1979657178 cites W2418706314 @default.
- W1979657178 cites W2609586546 @default.
- W1979657178 cites W72802891 @default.
- W1979657178 doi "https://doi.org/10.1210/endo-128-5-2633" @default.
- W1979657178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2019268" @default.
- W1979657178 hasPublicationYear "1991" @default.
- W1979657178 type Work @default.
- W1979657178 sameAs 1979657178 @default.
- W1979657178 citedByCount "40" @default.
- W1979657178 countsByYear W19796571782013 @default.
- W1979657178 countsByYear W19796571782016 @default.
- W1979657178 countsByYear W19796571782020 @default.
- W1979657178 crossrefType "journal-article" @default.
- W1979657178 hasAuthorship W1979657178A5005625193 @default.
- W1979657178 hasAuthorship W1979657178A5016647678 @default.
- W1979657178 hasAuthorship W1979657178A5020437320 @default.
- W1979657178 hasConcept C126322002 @default.
- W1979657178 hasConcept C134018914 @default.
- W1979657178 hasConcept C146957229 @default.
- W1979657178 hasConcept C178790620 @default.
- W1979657178 hasConcept C185592680 @default.
- W1979657178 hasConcept C2778534260 @default.
- W1979657178 hasConcept C2780091579 @default.
- W1979657178 hasConcept C2780959883 @default.
- W1979657178 hasConcept C540031477 @default.
- W1979657178 hasConcept C71924100 @default.
- W1979657178 hasConcept C7836513 @default.
- W1979657178 hasConcept C86803240 @default.
- W1979657178 hasConceptScore W1979657178C126322002 @default.
- W1979657178 hasConceptScore W1979657178C134018914 @default.
- W1979657178 hasConceptScore W1979657178C146957229 @default.
- W1979657178 hasConceptScore W1979657178C178790620 @default.
- W1979657178 hasConceptScore W1979657178C185592680 @default.
- W1979657178 hasConceptScore W1979657178C2778534260 @default.
- W1979657178 hasConceptScore W1979657178C2780091579 @default.
- W1979657178 hasConceptScore W1979657178C2780959883 @default.
- W1979657178 hasConceptScore W1979657178C540031477 @default.
- W1979657178 hasConceptScore W1979657178C71924100 @default.
- W1979657178 hasConceptScore W1979657178C7836513 @default.
- W1979657178 hasConceptScore W1979657178C86803240 @default.
- W1979657178 hasIssue "5" @default.
- W1979657178 hasLocation W19796571781 @default.
- W1979657178 hasLocation W19796571782 @default.
- W1979657178 hasOpenAccess W1979657178 @default.
- W1979657178 hasPrimaryLocation W19796571781 @default.
- W1979657178 hasRelatedWork W1552381745 @default.
- W1979657178 hasRelatedWork W1588725841 @default.
- W1979657178 hasRelatedWork W1592859225 @default.
- W1979657178 hasRelatedWork W1602405375 @default.
- W1979657178 hasRelatedWork W2033945997 @default.
- W1979657178 hasRelatedWork W2051884508 @default.
- W1979657178 hasRelatedWork W2085281796 @default.
- W1979657178 hasRelatedWork W2179797810 @default.
- W1979657178 hasRelatedWork W2415995798 @default.
- W1979657178 hasRelatedWork W4256664370 @default.
- W1979657178 hasVolume "128" @default.
- W1979657178 isParatext "false" @default.
- W1979657178 isRetracted "false" @default.
- W1979657178 magId "1979657178" @default.
- W1979657178 workType "article" @default.