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• W1979658052 abstract "The interactions between PDZ (PSD-95, Dlg, ZO-1) domains and PDZ-binding motifs play central roles in signal transductions within cells. Proteins with PDZ domains bind to PDZ-binding motifs almost exclusively when the motifs are located at the carboxyl (C-) terminal ends of their binding partners. However, it remains little explored whether PDZ-binding motifs show any preferential location at the C-terminal ends of proteins, at genome-level.Here, we examined the distribution of the type-I (x-x-S/T-x-I/L/V) or type-II (x-x-V-x-I/V) PDZ-binding motifs in proteins encoded in the genomes of five different species (human, mouse, zebrafish, fruit fly and nematode). We first established that these PDZ-binding motifs are indeed preferentially present at their C-terminal ends. Moreover, we found specific amino acid (AA) bias for the 'x' positions in the motifs at the C-terminal ends. In general, hydrophilic AAs were favored. Our genomics-based findings confirm and largely extend the results of previous interaction-based studies, allowing us to propose refined consensus sequences for all of the examined PDZ-binding motifs. An ontological analysis revealed that the refined motifs are functionally relevant since a large fraction of the proteins bearing the motif appear to be involved in signal transduction. Furthermore, co-precipitation experiments confirmed two new protein interactions predicted by our genomics-based approach. Finally, we show that influenza virus pathogenicity can be correlated with PDZ-binding motif, with high-virulence viral proteins bearing a refined PDZ-binding motif.Our refined definition of PDZ-binding motifs should provide important clues for identifying functional PDZ-binding motifs and proteins involved in signal transduction." @default.
• W1979658052 created "2016-06-24" @default.
• W1979658052 creator A5011594864 @default.
• W1979658052 creator A5040004606 @default.
• W1979658052 creator A5087218338 @default.
• W1979658052 date "2011-06-08" @default.
• W1979658052 modified "2023-10-06" @default.
• W1979658052 title "Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif" @default.
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• W1979658052 doi "https://doi.org/10.1186/1471-2164-12-300" @default.
• W1979658052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3138430" @default.
• W1979658052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21649932" @default.
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