Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979659640> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1979659640 endingPage "124" @default.
- W1979659640 startingPage "115" @default.
- W1979659640 abstract "Varying dosages of pentasaccharide (400-800 nmol/kg) were compared to a 250-U/kg single bolus dosage of unfractionated heparin (UFH) in a dog model of hemodialysis. Several laboratory assays were used to monitor the effects of pentasaccharide and UFH. The pentasaccharide did not produce any anticoagulant effects as measured by the activated partial thromboplastin time. However, in the anti-Xa chromogenic assay and the Heptest assays, there was a dose-dependent prolongation after pentasaccharide administration. In the group of dogs administered 800 nmol/kg of pentasaccharide, there was a 50% decrease in the thrombin antithrombin (TAT) complex level after 60 minutes on dialysis. In the UFH-treated dogs, wide variations in assays were observed. There was a marked elevation in the activated partial thromboplastin time and Heptest assays up to 6 hours after UFH administration. Both anti-Xa and anti-IIa activity was measured up to 4 hours. In the TAT assay, UFH was found to have a stronger effect in suppressing the formation of TAT in comparison to the pentasaccharide. These results suggest that pentasaccharide can be used as a replacement for UFH in a dog model of hemodialysis to keep the dialysis circuit patent. In addition, the anti-Xa-based assays such as the Heptest and the chromogenic anti-Xa assays can be used to monitor the effects of pentasaccharide in this model." @default.
- W1979659640 created "2016-06-24" @default.
- W1979659640 creator A5007859032 @default.
- W1979659640 creator A5026199225 @default.
- W1979659640 creator A5030457785 @default.
- W1979659640 creator A5031068444 @default.
- W1979659640 creator A5035601487 @default.
- W1979659640 creator A5048913438 @default.
- W1979659640 creator A5064983817 @default.
- W1979659640 creator A5074304553 @default.
- W1979659640 date "1999-10-01" @default.
- W1979659640 modified "2023-09-27" @default.
- W1979659640 title "Laboratory Monitoring of Pentasaccharide in a Dog Model of Hemodialysis" @default.
- W1979659640 cites W1833703938 @default.
- W1979659640 cites W1972270077 @default.
- W1979659640 cites W2012257575 @default.
- W1979659640 cites W2013327374 @default.
- W1979659640 cites W2025768989 @default.
- W1979659640 cites W2049557763 @default.
- W1979659640 cites W2059591383 @default.
- W1979659640 cites W2066067563 @default.
- W1979659640 cites W2108471572 @default.
- W1979659640 cites W2149491841 @default.
- W1979659640 cites W2237516276 @default.
- W1979659640 cites W2328886953 @default.
- W1979659640 cites W2333983635 @default.
- W1979659640 cites W2460422351 @default.
- W1979659640 doi "https://doi.org/10.1016/s0049-3848(99)00094-8" @default.
- W1979659640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10574589" @default.
- W1979659640 hasPublicationYear "1999" @default.
- W1979659640 type Work @default.
- W1979659640 sameAs 1979659640 @default.
- W1979659640 citedByCount "6" @default.
- W1979659640 countsByYear W19796596402012 @default.
- W1979659640 crossrefType "journal-article" @default.
- W1979659640 hasAuthorship W1979659640A5007859032 @default.
- W1979659640 hasAuthorship W1979659640A5026199225 @default.
- W1979659640 hasAuthorship W1979659640A5030457785 @default.
- W1979659640 hasAuthorship W1979659640A5031068444 @default.
- W1979659640 hasAuthorship W1979659640A5035601487 @default.
- W1979659640 hasAuthorship W1979659640A5048913438 @default.
- W1979659640 hasAuthorship W1979659640A5064983817 @default.
- W1979659640 hasAuthorship W1979659640A5074304553 @default.
- W1979659640 hasConcept C126322002 @default.
- W1979659640 hasConcept C128463046 @default.
- W1979659640 hasConcept C185592680 @default.
- W1979659640 hasConcept C2777557582 @default.
- W1979659640 hasConcept C2778063415 @default.
- W1979659640 hasConcept C2778205648 @default.
- W1979659640 hasConcept C2778261982 @default.
- W1979659640 hasConcept C2779026020 @default.
- W1979659640 hasConcept C2779978075 @default.
- W1979659640 hasConcept C2780077467 @default.
- W1979659640 hasConcept C42219234 @default.
- W1979659640 hasConcept C43376680 @default.
- W1979659640 hasConcept C43617362 @default.
- W1979659640 hasConcept C55493867 @default.
- W1979659640 hasConcept C71924100 @default.
- W1979659640 hasConcept C89560881 @default.
- W1979659640 hasConcept C98274493 @default.
- W1979659640 hasConceptScore W1979659640C126322002 @default.
- W1979659640 hasConceptScore W1979659640C128463046 @default.
- W1979659640 hasConceptScore W1979659640C185592680 @default.
- W1979659640 hasConceptScore W1979659640C2777557582 @default.
- W1979659640 hasConceptScore W1979659640C2778063415 @default.
- W1979659640 hasConceptScore W1979659640C2778205648 @default.
- W1979659640 hasConceptScore W1979659640C2778261982 @default.
- W1979659640 hasConceptScore W1979659640C2779026020 @default.
- W1979659640 hasConceptScore W1979659640C2779978075 @default.
- W1979659640 hasConceptScore W1979659640C2780077467 @default.
- W1979659640 hasConceptScore W1979659640C42219234 @default.
- W1979659640 hasConceptScore W1979659640C43376680 @default.
- W1979659640 hasConceptScore W1979659640C43617362 @default.
- W1979659640 hasConceptScore W1979659640C55493867 @default.
- W1979659640 hasConceptScore W1979659640C71924100 @default.
- W1979659640 hasConceptScore W1979659640C89560881 @default.
- W1979659640 hasConceptScore W1979659640C98274493 @default.
- W1979659640 hasIssue "2" @default.
- W1979659640 hasLocation W19796596401 @default.
- W1979659640 hasLocation W19796596402 @default.
- W1979659640 hasOpenAccess W1979659640 @default.
- W1979659640 hasPrimaryLocation W19796596401 @default.
- W1979659640 hasRelatedWork W151574171 @default.
- W1979659640 hasRelatedWork W1721577355 @default.
- W1979659640 hasRelatedWork W1976696402 @default.
- W1979659640 hasRelatedWork W1979977195 @default.
- W1979659640 hasRelatedWork W1994434805 @default.
- W1979659640 hasRelatedWork W2055297044 @default.
- W1979659640 hasRelatedWork W2078234031 @default.
- W1979659640 hasRelatedWork W2123421678 @default.
- W1979659640 hasRelatedWork W2266834756 @default.
- W1979659640 hasRelatedWork W2324795260 @default.
- W1979659640 hasVolume "96" @default.
- W1979659640 isParatext "false" @default.
- W1979659640 isRetracted "false" @default.
- W1979659640 magId "1979659640" @default.
- W1979659640 workType "article" @default.