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• W1979659675 abstract "The Hox11 paralogous genes play critical roles in kidney development. They are expressed in the early metanephric mesenchyme and are required for the induction of ureteric bud formation and its subsequent branching morphogenesis. They are also required for the normal nephrogenesis response of the metanephric mesenchyme to inductive signals from the ureteric bud. In this report, we use microarrays to perform a comprehensive gene expression analysis of the Hoxa11/Hoxd11 mutant kidney phenotype. We examined E11.5, E12.5, E13.5 and E16.5 developmental time points. A novel high throughput strategy for validation of microarray data is described, using additional biological replicates and an independent microarray platform. The results identified 13 genes with greater than 3-fold change in expression in early mutant kidneys, including Hoxa11s, GATA6, TGFbeta2, chemokine ligand 12, angiotensin receptor like 1, cytochrome P450, cadherin5, and Lymphocyte antigen 6 complex, Iroquois 3, EST A930038C07Rik, Meox2, Prkcn, and Slc40a1. Of interest, many of these genes, and others showing lower fold expression changes, have been connected to processes that make sense in terms of the mutant phenotype, including TGFbeta signaling, iron transport, protein kinase C function, growth arrest and GDNF regulation. These results identify the multiple molecular pathways downstream of Hox11 function in the developing kidney." @default.
• W1979659675 created "2016-06-24" @default.
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• W1979659675 date "2006-05-01" @default.
• W1979659675 modified "2023-09-27" @default.
• W1979659675 title "Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development" @default.
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• W1979659675 cites W1561598641 @default.
• W1979659675 cites W1566475950 @default.
• W1979659675 cites W1575754639 @default.
• W1979659675 cites W1908134412 @default.
• W1979659675 cites W1927481352 @default.
• W1979659675 cites W1931597824 @default.
• W1979659675 cites W1950995033 @default.
• W1979659675 cites W1966312815 @default.
• W1979659675 cites W1971689970 @default.
• W1979659675 cites W1974659616 @default.
• W1979659675 cites W1976532923 @default.
• W1979659675 cites W1977466966 @default.
• W1979659675 cites W1978871485 @default.
• W1979659675 cites W1982210644 @default.
• W1979659675 cites W1982746675 @default.
• W1979659675 cites W1983228128 @default.
• W1979659675 cites W1986625228 @default.
• W1979659675 cites W1987566228 @default.
• W1979659675 cites W1992711566 @default.
• W1979659675 cites W1998282976 @default.
• W1979659675 cites W1999466077 @default.
• W1979659675 cites W2001071540 @default.
• W1979659675 cites W2007389030 @default.
• W1979659675 cites W2007635230 @default.
• W1979659675 cites W2011028864 @default.
• W1979659675 cites W2011813261 @default.
• W1979659675 cites W2020263168 @default.
• W1979659675 cites W2020422405 @default.
• W1979659675 cites W2022689175 @default.
• W1979659675 cites W2024593057 @default.
• W1979659675 cites W2024675721 @default.
• W1979659675 cites W2025273598 @default.
• W1979659675 cites W2027088025 @default.
• W1979659675 cites W2027322371 @default.
• W1979659675 cites W2035951460 @default.
• W1979659675 cites W2038059446 @default.
• W1979659675 cites W2039309643 @default.
• W1979659675 cites W2043072647 @default.
• W1979659675 cites W2048814659 @default.
• W1979659675 cites W2051998916 @default.
• W1979659675 cites W2061731694 @default.
• W1979659675 cites W2066484100 @default.
• W1979659675 cites W2067595882 @default.
• W1979659675 cites W2070533226 @default.
• W1979659675 cites W2070863782 @default.
• W1979659675 cites W2074060582 @default.
• W1979659675 cites W2076374439 @default.
• W1979659675 cites W2082584428 @default.
• W1979659675 cites W2083356835 @default.
• W1979659675 cites W2085449121 @default.
• W1979659675 cites W2092928837 @default.
• W1979659675 cites W2099006894 @default.
• W1979659675 cites W2100847259 @default.
• W1979659675 cites W2101314011 @default.
• W1979659675 cites W2106069796 @default.
• W1979659675 cites W2107277218 @default.
• W1979659675 cites W2109194190 @default.
• W1979659675 cites W2111122566 @default.
• W1979659675 cites W2112150809 @default.
• W1979659675 cites W2118717572 @default.
• W1979659675 cites W2120045068 @default.
• W1979659675 cites W2120865735 @default.
• W1979659675 cites W2122588714 @default.
• W1979659675 cites W2124852687 @default.
• W1979659675 cites W2140328948 @default.
• W1979659675 cites W2140554702 @default.
• W1979659675 cites W2141383211 @default.
• W1979659675 cites W2143508168 @default.
• W1979659675 cites W2144212283 @default.
• W1979659675 cites W2144260292 @default.
• W1979659675 cites W2147347845 @default.
• W1979659675 cites W2151297727 @default.
• W1979659675 cites W2160028522 @default.
• W1979659675 cites W2160029256 @default.
• W1979659675 cites W2169599062 @default.
• W1979659675 cites W2186049400 @default.
• W1979659675 cites W2328187165 @default.
• W1979659675 cites W2344364145 @default.
• W1979659675 cites W2345807603 @default.
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• W1979659675 doi "https://doi.org/10.1016/j.ydbio.2006.02.023" @default.
• W1979659675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16581055" @default.
• W1979659675 hasPublicationYear "2006" @default.
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