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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979668077> ?p ?o ?g. }

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• W1979668077 abstract "In Saccharomyces cerevisiae the Gid-complex functions as an ubiquitin-ligase complex that regulates the metabolic switch between glycolysis and gluconeogenesis. In higher organisms six conserved Gid proteins form the CTLH protein-complex with unknown function. Here we show that Rmnd5, the Gid2 orthologue from Xenopus laevis, is an ubiquitin-ligase embedded in a high molecular weight complex. Expression of rmnd5 is strongest in neuronal ectoderm, prospective brain, eyes and ciliated cells of the skin and its suppression results in malformations of the fore- and midbrain. We therefore suggest that Xenopus laevis Rmnd5, as a subunit of the CTLH complex, is a ubiquitin-ligase targeting an unknown factor for polyubiquitination and subsequent proteasomal degradation for proper fore- and midbrain development." @default.
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• W1979668077 date "2015-03-20" @default.
• W1979668077 modified "2023-10-01" @default.
• W1979668077 title "RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development" @default.
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• W1979668077 doi "https://doi.org/10.1371/journal.pone.0120342" @default.
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