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- W1979674117 abstract "Abstract Desmopressin (DDAVP) is a synthetic analogue of arginine vasopressin (AVP) that is indicated for the treatment of diabetes insipidus, nocturnal enuresis, and some hemostatic disorders. Some activities of DDAVP are attributed to the interaction with the AVP cell surface receptor; other activities are uncertain. In the present study we investigated the effect of DDAVP on rat brain synaptosomal membranes by means of a fluorescence technique. The membrane fluidity of synaptosomal membranes was studied by measuring the steady-state fluorescence anisotropy of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene incorporated into the membrane. The results show that the addition of DDAVP (10 −6 mol/L) induced a significant and time-limited increase in the lipid order in the exterior part of the membrane. These data demonstrate that DDAVP interacts with synaptosomal membranes. It is reasonable to propose that this interaction induces changes in cell response or function. Further studies are needed to elucidate the molecular basis of this effect." @default.
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- W1979674117 date "1998-03-01" @default.
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- W1979674117 title "Effect of desmopressin on rat brain synaptosomal membranes: a pilot study" @default.
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- W1979674117 doi "https://doi.org/10.1016/s0011-393x(98)85013-3" @default.
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