Matches in SemOpenAlex for { <https://semopenalex.org/work/W1979681605> ?p ?o ?g. }
- W1979681605 endingPage "353" @default.
- W1979681605 startingPage "345" @default.
- W1979681605 abstract "Tumor necrosis factor-alpha (TNF-alpha) depresses myocardial contractility, and overexpression of TNF-alpha in the myocardium contributes to cardiac dysfunction caused by both systemic and local insults. Sepsis, endotoxemia, hemorrhagic shock, and myocardial ischemia-reperfusion all promote cardiac dysfunction in part by a TNF-alpha-mediated mechanism. Thus, TNF-alpha represents an appealing therapeutic target for myocardial protection against multiple clinically relevant insults. The inducible 70-kD heat shock protein (Hsp70) is expressed in the myocardium in response to stress and has been linked to enhanced myocardial resistance to depression associated with ischemia-reperfusion or sepsis. The mechanism by which Hsp70 protects cardiac function against a subsequent insult remains obscure. In vitro induction of Hsp70 in monocytes or macrophages inhibits TNF-alpha production following bacterial lipopolysaccharide stimulation, and in vivo induction of Hsp70 down-regulates tissue TNF-alpha production following an injurious insult. Understanding of the regulatory role of Hsp70 in the myocardial inflammatory response will provide insights into the mechanism by which Hsp70 preserves cardiac function and may yield therapies for protection of the myocardium against depression associated injurious insults." @default.
- W1979681605 created "2016-06-24" @default.
- W1979681605 creator A5069922286 @default.
- W1979681605 creator A5087253902 @default.
- W1979681605 date "2002-05-01" @default.
- W1979681605 modified "2023-10-09" @default.
- W1979681605 title "The Interaction Between HSP70 and TNF-?? Expression: A Novel Mechanism for Protection of the Myocardium Against Post-Injury Depression" @default.
- W1979681605 cites W1486595828 @default.
- W1979681605 cites W1513020808 @default.
- W1979681605 cites W1515599953 @default.
- W1979681605 cites W1523923451 @default.
- W1979681605 cites W1582274792 @default.
- W1979681605 cites W1775507621 @default.
- W1979681605 cites W1955941410 @default.
- W1979681605 cites W1966502113 @default.
- W1979681605 cites W1967128858 @default.
- W1979681605 cites W1967883278 @default.
- W1979681605 cites W1968940913 @default.
- W1979681605 cites W1974490952 @default.
- W1979681605 cites W1979520552 @default.
- W1979681605 cites W1982062664 @default.
- W1979681605 cites W1982260690 @default.
- W1979681605 cites W1982799442 @default.
- W1979681605 cites W1983665288 @default.
- W1979681605 cites W1985204948 @default.
- W1979681605 cites W1985918663 @default.
- W1979681605 cites W1986289438 @default.
- W1979681605 cites W1988262861 @default.
- W1979681605 cites W1990280006 @default.
- W1979681605 cites W1990315727 @default.
- W1979681605 cites W1994430830 @default.
- W1979681605 cites W1996363544 @default.
- W1979681605 cites W1997485025 @default.
- W1979681605 cites W2003088600 @default.
- W1979681605 cites W2003206167 @default.
- W1979681605 cites W2006887827 @default.
- W1979681605 cites W2006919847 @default.
- W1979681605 cites W2010237936 @default.
- W1979681605 cites W2012972054 @default.
- W1979681605 cites W2016224818 @default.
- W1979681605 cites W2017033551 @default.
- W1979681605 cites W2018538582 @default.
- W1979681605 cites W2019951936 @default.
- W1979681605 cites W2020012059 @default.
- W1979681605 cites W2021858086 @default.
- W1979681605 cites W2023002615 @default.
- W1979681605 cites W2023715856 @default.
- W1979681605 cites W2024120290 @default.
- W1979681605 cites W2025899545 @default.
- W1979681605 cites W2029265132 @default.
- W1979681605 cites W2030852470 @default.
- W1979681605 cites W2031353853 @default.
- W1979681605 cites W2033150773 @default.
- W1979681605 cites W2035120325 @default.
- W1979681605 cites W2035616122 @default.
- W1979681605 cites W2036909269 @default.
- W1979681605 cites W2038189746 @default.
- W1979681605 cites W2038434279 @default.
- W1979681605 cites W2038532324 @default.
- W1979681605 cites W2039796621 @default.
- W1979681605 cites W2045356063 @default.
- W1979681605 cites W2046639009 @default.
- W1979681605 cites W2047547145 @default.
- W1979681605 cites W2051002291 @default.
- W1979681605 cites W2051836134 @default.
- W1979681605 cites W2052596629 @default.
- W1979681605 cites W2055533988 @default.
- W1979681605 cites W2058185635 @default.
- W1979681605 cites W2059030223 @default.
- W1979681605 cites W2060071007 @default.
- W1979681605 cites W2061738083 @default.
- W1979681605 cites W2067506632 @default.
- W1979681605 cites W2068028252 @default.
- W1979681605 cites W2068718379 @default.
- W1979681605 cites W2070176859 @default.
- W1979681605 cites W2070446231 @default.
- W1979681605 cites W2071407810 @default.
- W1979681605 cites W2072001004 @default.
- W1979681605 cites W2073802004 @default.
- W1979681605 cites W2076659569 @default.
- W1979681605 cites W2079321385 @default.
- W1979681605 cites W2081777643 @default.
- W1979681605 cites W2083553869 @default.
- W1979681605 cites W2088227226 @default.
- W1979681605 cites W2111858669 @default.
- W1979681605 cites W2117637609 @default.
- W1979681605 cites W2119275339 @default.
- W1979681605 cites W2120751716 @default.
- W1979681605 cites W2121966916 @default.
- W1979681605 cites W2126636055 @default.
- W1979681605 cites W2126942951 @default.
- W1979681605 cites W2135725482 @default.
- W1979681605 cites W2140735579 @default.
- W1979681605 cites W2148823498 @default.
- W1979681605 cites W2151884159 @default.
- W1979681605 cites W2152658552 @default.
- W1979681605 cites W2152891521 @default.
- W1979681605 cites W2155160672 @default.