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• W1979686921 abstract "Crigler–Najjar syndrome type I is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia beginning at birth. The syndrome results from an absence of hepatic uridine diphosphoglucuronate (UDP) glucuronosyltransferase activity, which is essential for the conjugation and excretion of bilirubin. Because of the accumulation of unconjugated bilirubin in plasma, patients are at risk for kernicterus.1 Although phototherapy successfully reduces serum bilirubin levels, patients are again at risk for kernicterus around the time of puberty, when phototherapy becomes less effective.2 The necessary daily duration of phototherapy often approaches 14 to 16 hours. At present, liver transplantation is the only definitive treatment. . . ." @default.
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• W1979686921 date "1998-05-14" @default.
• W1979686921 modified "2023-10-17" @default.
• W1979686921 title "Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation" @default.
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• W1979686921 doi "https://doi.org/10.1056/nejm199805143382004" @default.
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