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• W1979687510 abstract "The epithelial-mesenchymal transition (EMT) is a crucial event that occurs during cancer metastasis and can be induced by transforming growth factor-β (TGF-β) in various tumor cells in vitro. However, little is known about the effects of TGF-β in canine mammary gland tumors (CMGTs). Here, we investigated the role of TGF-β in CMGT. We observed that treatment of the CMGT cell line CHMp13a with TGF-β1 leads to transient induction of the mesenchymal marker vimentin. Real-time measurements of cellular electrical impedance also showed that CMGT invasiveness is transiently increased by TGF-β1 treatment, but is reversed after prolonged stimulation. This phenomenon is similar to the mesenchymal-epithelial transition (MET, the reverse phenomenon of EMT), and a process that is implicated in the establishment of secondary metastatic lesions." @default.
• W1979687510 created "2016-06-24" @default.
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• W1979687510 date "2013-06-01" @default.
• W1979687510 modified "2023-10-17" @default.
• W1979687510 title "Transforming growth factor-β transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line" @default.
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• W1979687510 doi "https://doi.org/10.1016/j.rvsc.2012.10.016" @default.
• W1979687510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23182613" @default.
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